Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Timur Ermatov; Roman E. Noskov; Andrey A. Machnev; Ivan Gnusov; Vsevolod Аtkin; Ekaterina N. Lazareva; Sergei V. German; Sergey S. Kosolobov; Timofei S. Zatsepin; Olga V. Sergeeva; Julia S. Skibina; Pavel Ginzburg; Valery V. Tuchin; Pavlos G. Lagoudakis; Dmitry A. Gorin

doi:10.1038/s41377-020-00410-8

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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Original Articles

- Multispectral sensing of biological liquids with hollow-core microstructured optical fibres
- Light: Science & Applications Vol. 9, Issue 5, Pages: 1661-1672(2020)
- Affiliations：
  
  1.Skolkovo Institute of Science and Technology, 3 Nobelya str., Moscow 121205, Russia
  2.Department of Electrical Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
  3.Light-Matter Interaction Centre, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
  4.Saratov State University, 83 Astrakhanskaya str., Saratov 410012, Russia
  5.Tomsk State University, 36 Lenin's av., Tomsk 634050, Russia
  6.M.V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119992, Russia
  7.SPE LLC Nanostructured Glass Technology, 101 50 Let Oktjabrja, Saratov 410033, Russia
  8.Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia
  9.Institute of Precision Mechanics and Control of the Russian Academy of Sciences, 24 Rabochaya str., Saratov 410028, Russia
- Author bio：
  
  Dmitry A. Gorin (d.gorin@skoltech.ru)
- Funds：
- DOI：10.1038/s41377-020-00410-8
  CLC：
- Published：2020，
  
  Published Online：10 October 2020，
  
  Received：12 May 2020，
  
  Revised：17 September 2020，
  
  Accepted：24 September 2020
- Accepted：
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Ermatov, T. et al. Multispectral sensing of biological liquids with hollow-core microstructured optical fibres. Light: Science & Applications, 9, 1661-1672 (2020).
DOI：

Ermatov, T. et al. Multispectral sensing of biological liquids with hollow-core microstructured optical fibres. Light: Science & Applications, 9, 1661-1672 (2020). DOI： 10.1038/s41377-020-00410-8.

摘要

Abstract

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy

however

disregards the promising possibility of simultaneous measurements of a bioanalyte's refractive index over a broadband spectral domain. Here

we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths

with a sensitivity up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU

−1

in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

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Keywords

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