High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots

Xianglong Miao; Lingyue Yan; Yun Wu; Peter Q. Liu

doi:10.1038/s41377-020-00449-7

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High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots

Articles

- High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots
- Light: Science & Applications Vol. 10, Issue 1, Pages: 60-70(2021)
- Affiliations：
  
  1.Department of Electrical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
  2.Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
- Author bio：
  
  Peter Q. Liu (pqliu@buffalo.edu)
- Funds：
- DOI：10.1038/s41377-020-00449-7
  CLC：
- Published：2021，
  
  Published Online：05 January 2021，
  
  Received：12 August 2020，
  
  Revised：25 November 2020，
  
  Accepted：01 December 2020
- Accepted：
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Miao, X. L. et al. High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots. Light: Science & Applications, 10, 60-70 (2021).
DOI：

Miao, X. L. et al. High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots. Light: Science & Applications, 10, 60-70 (2021). DOI： 10.1038/s41377-020-00449-7.

摘要

Abstract

Nanophotonic resonators can confine light to deep-subwavelength volumes with highly enhanced near-field intensity and therefore are widely used for surface-enhanced infrared absorption spectroscopy in various molecular sensing applications. The enhanced signal is mainly contributed by molecules in photonic hot spots

which are regions of a nanophotonic structure with high-field intensity. Therefore

delivery of the majority of

if not all

analyte molecules to hot spots is crucial for fully utilizing the sensing capability of an optical sensor. However

for most optical sensors

simple and straightforward methods of introducing an aqueous analyte to the device

such as applying droplets or spin-coating

cannot achieve targeted delivery of analyte molecules to hot spots. Instead

analyte molecules are usually distributed across the entire device surface

so the majority of the molecules do not experience enhanced field intensity. Here

we present a nanophotonic sensor design with passive molecule trapping functionality. When an analyte solution droplet is introduced to the sensor surface and gradually evaporates

the device structure can effectively trap most precipitated analyte molecules in its hot spots

significantly enhancing the sensor spectral response and sensitivity performance. Specifically

our sensors produce a reflection change of a few percentage points in response to trace amounts of the amino-acid proline or glucose precipitate with a picogram-level mass

which is significantly less than the mass of a molecular monolayer covering the same measurement area. The demonstrated strategy for designing optical sensor structures may also be applied to sensing nano-particles such as exosomes

viruses

and quantum dots.

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Keywords

references

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