Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

Elisabet A. Rank; Ryan Sentosa; Danielle J. Harper; Matthias Salas; Anna Gaugutz; Dana Seyringer; Stefan Nevlacsil; Alejandro Maese-Novo; Moritz Eggeling; Paul Muellner; Rainer Hainberger; Martin Sagmeister; Jochen Kraft; Rainer A. Leitgeb; Wolfgang Drexler

doi:10.1038/s41377-020-00450-0

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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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- Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings
- Light: Science & Applications Vol. 10, Issue 1, Pages: 71-85(2021)
- Affiliations：
  
  1.Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4 L, 1090 Vienna, Austria
  2.Research Centre for Microtechnology, Vorarlberg University of Applied Sciences, Hochschulstrasse 1, 6850 Dornbirn, Austria
  3.AIT Austrian Institute of Technology GmbH, Gieffinggasse 4, 1210 Vienna, Austria
  4.ams AG, Tobelbader Strasse 30, 8141 Premstaetten, Austria
- Author bio：
  
  Elisabet A. Rank (elisabet.rank@meduniwien.ac.at)
- Funds：
- DOI：10.1038/s41377-020-00450-0
  CLC：
- Published：2021，
  
  Published Online：05 January 2021，
  
  Received：27 March 2020，
  
  Revised：14 November 2020，
  
  Accepted：03 December 2020
- Accepted：
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Rank, E. A. et al. Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings. Light: Science & Applications, 10, 71-85 (2021).
DOI：

Rank, E. A. et al. Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings. Light: Science & Applications, 10, 71-85 (2021). DOI： 10.1038/s41377-020-00450-0.

摘要

Abstract

In this work

we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256

channels were tested

which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm

with which a sensitivity of up to 91 dB (830 µW

)

and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm

with which a sensitivity of 90 dB (480 µW

)

and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process

which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography

tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

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Keywords

references

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