Ultrahigh-sensitive optical coherence elastography

Yan Li; Sucbei Moon; Jason J. Chen; Zhikai Zhu; Zhongping Chen

doi:10.1038/s41377-020-0297-9

Go to Nature Website

Your Location：

Home >

Browse articles >

Ultrahigh-sensitive optical coherence elastography

Original Articles

- Ultrahigh-sensitive optical coherence elastography
- Light: Science & Applications Vol. 9, Issue 3, Pages: 610-619(2020)
- Affiliations：
  
  1.Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612, USA
  2.Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA
  3.Department of Physics, Kookmin University, Seoul 02707, South Korea
- Author bio：
  
  Zhongping Chen (z2chen@uci.edu)
- Funds：
- DOI：10.1038/s41377-020-0297-9
  CLC：
- Published：2020，
  
  Published Online：13 April 2020，
  
  Received：29 October 2019，
  
  Revised：16 March 2020，
  
  Accepted：19 March 2020
- Accepted：
Scan QR Code
Li, Y. et al. Ultrahigh-sensitive optical coherence elastography. Light: Science & Applications, 9, 610-619 (2020).
DOI：

Li, Y. et al. Ultrahigh-sensitive optical coherence elastography. Light: Science & Applications, 9, 610-619 (2020). DOI： 10.1038/s41377-020-0297-9.

摘要

Abstract

The phase stability of an optical coherence elastography (OCE) system is the key determining factor for achieving a precise elasticity measurement

and it can be affected by the signal-to-noise ratio (SNR)

timing jitters in the signal acquisition process

and fluctuations in the optical path difference (OPD) between the sample and reference arms. In this study

we developed an OCE system based on swept-source optical coherence tomography (SS-OCT) with a common-path configuration (SS-OCE

). Our system has a phase stability of 4.2 mrad without external stabilization or extensive post-processing

such as averaging. This phase stability allows us to detect a displacement as small as ~300 pm. A common-path interferometer was incorporated by integrating a 3-mm wedged window into the SS-OCT system to provide intrinsic compensation for polarization and dispersion mismatch

as well as to minimize phase fluctuations caused by the OPD variation. The wedged window generates two reference signals that produce two OCT images

allowing for averaging to improve the SNR. Furthermore

the electrical components are optimized to minimize the timing

jitters and prevent edge collisions by adjusting the delays between the trigger

k-clock

and signal

utilizing a high-speed waveform digitizer

and incorporating a high-bandwidth balanced photodetector. We validated the SS-OCE

performance in a tissue-mimicking phantom and an in vivo rabbit model

and the results demonstrated a significantly improved phase stability compared to that of the conventional SS-OCE. To the best of our knowledge

we demonstrated the first SS-OCE

system

which possesses high-phase stability and can be utilized to significantly improve the sensitivity of elastography.

关键词

Keywords

references

Schmitt, J. M. OCT elastography: imaging microscopic deformation and strain of tissue.Opt. Express3, 199-211 (1998)..

Kennedy, B. F., Wijesinghe, P.&Sampson, D. D. The emergence of optical elastography in biomedicine.Nat. Photonics11, 215-221 (2017)..

Feng, Y. et al. Viscoelastic properties of the ferret brain measured in vivo at multiple frequencies by magnetic resonance elastography.J. Biomech.46, 863-870 (2013)..

Zhang, X. Y. et al. Noninvasive assessment of age-related stiffness of crystalline lenses in a rabbit model using ultrasound elastography.Biomed. Eng. OnLine17, 75 (2018)..

Yun, S. H.&Chernyak, D. Brillouin microscopy: assessing ocular tissue biomechanics.Curr. Opin. Ophthalmol.29, 299-305 (2018)..

Muthupillai, R.&Ehman, R. L. Magnetic resonance elastography.Nat. Med.2, 601-603 (1996)..

Qu, Y. Q. et al. Acoustic radiation force optical coherence elastography of corneal tissue.IEEE J. Sel. Top. Quantum Electron.22, 6803507 (2016)..

Kirby, M. A. et al. Optical coherence elastography in ophthalmology.J. Biomed. Opt.22, 121720 (2017)..

Qu, Y. Q. et al. Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography.Sci. Rep.7, 4731 (2017)..

Song, S. Z. et al. Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate.Appl. Phys. Lett.108, 191104 (2016)..

Zhao, Y. H. et al. Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity.Opt. Lett.25, 114-116 (2000)..

Szkulmowska, A. et al. Phase-resolved Doppler optical coherence tomography-limitations and improvements.Opt. Lett.33, 1425-1427 (2008)..

Qu, Y. Q. et al. In vivo elasticity mapping of posterior ocular layers using acoustic radiation force optical coherence elastography.Investigative Ophthalmol. Vis. Sci.59, 455-461 (2018)..

Li, Y. et al. Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation.APL Photonics4, 106104 (2019)..

He, Y. M. et al. Confocal shear wave acoustic radiation force optical coherence elastography for imaging and quantification of the in vivo posterior eye.IEEE J. Sel. Top. Quantum Electron.25, 7200107 (2019)..

Kang, J. U. et al. Common-path optical coherence tomography for biomedical imaging and sensing.J. Optical Soc. Korea14, 1-13 (2010)..

Vakhtin, A. B. et al. Common-path interferometer for frequency-domain optical coherence tomography.Appl. Opt.42, 6953-6958 (2003)..

Tan, K. M. et al. In-fiber common-path optical coherence tomography using a conical-tip fiber.Opt. Express17, 2375-2384 (2009)..

Lan, G. P. et al. Common-path phase-sensitive optical coherence tomography provides enhanced phase stability and detection sensitivity for dynamic elastography.Biomed. Opt. Express8, 5253-5266 (2017)..

Leartprapun, N. et al.Photonic force optical coherence elastography for three-dimensional mechanical microscopy.Nat. Commun.9, 2079 (2018)..

Ahmad, A. et al. Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves.Biomed. Opt. Express5, 2349-2361 (2014)..

Zhang, H. Q. et al. Optical coherence elastography of cold cataract in porcine lens.J. Biomed. Opt.24, 036004 (2019)..

Qu, Y. Q. et al. Quantified elasticity mapping of retinal layers using synchronized acoustic radiation force optical coherence elastography.Biomed. Opt. Express9, 4054-4063 (2018)..

He, Y. M. et al. Characterization of oviduct ciliary beat frequency using real time phase resolved Doppler spectrally encoded interferometric microscopy.Biomed. Opt. Express10, 5650-5659 (2019)..

Hendargo, H. C. et al. Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography.Biomed. Opt. Express2, 2175-2188 (2011)..

De Boer, J. F., Leitgeb, R.&Wojtkowski, M. Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [Invited].Biomed. Opt. Express8, 3248-3280 (2017)..

Song, S. Z., Xu, J. J.&Wang, R. K. Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source.Biomed. Opt. Express7, 4734-4748 (2016)..

Tsai, M. T. et al. Quantitative phase imaging with swept-source optical coherence tomography for optical measurement of nanostructures.IEEE Photonics Technol. Lett.24, 640-642 (2012)..

De Stefano, V. S. et al. Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography.PLoS ONE13, e0209480 (2018)..

Razani, M. et al. Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms.Biomed. Opt. Express3, 972-980 (2012)..

Manapuram, R. K. et al.In vivoestimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography.J. Biomed. Opt.17, 100501 (2012)..

Zhu, J. et al. Coaxial excitation longitudinal shear wave measurement for quantitative elasticity assessment using phase-resolved optical coherence elastography.Opt. Lett.43, 2388-2391 (2018)..

Singh, M. et al. Evaluating the effects of Riboflavin/UV-A and Rose-Bengal/Green light cross-linking of the rabbit cornea by noncontact optical coherence elastography.Investigative Ophthalmol. Vis. Sci.57, OCT112-OCT120 (2016)..

Zhu, J. et al. Imaging and characterizing shear wave and shear modulus under orthogonal acoustic radiation force excitation using OCT doppler variance method.Opt. Lett.40, 2099-2102 (2015)..

Zhi, Z. W. et al. 4D optical coherence tomography-based micro-angiography achieved by 1.6-MHz FDML swept source.Opt. Lett.40, 1779-1782 (2015)..

Zhang, J. et al. High-dynamic-range quantitative phase imaging with spectral domain phase microscopy.Opt. Lett.34, 3442-3444 (2009)..

Ambroziński, Ł. et al. Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity.Sci. Rep.6, 38967 (2016)..

Moon, S.&Chen, Z. P. Phase-stability optimization of swept-source optical coherence tomography.Biomed. Opt. Express9, 5280-5295 (2018)..

Yang, J. M. et al. Photoacoustic endoscopy.Opt. Lett.34, 1591-1593 (2009)..

Li, Y. et al. PMN-PT/Epoxy 1-3 composite based ultrasonic transducer for dual-modality photoacoustic and ultrasound endoscopy.Photoacoustics15, 100138 (2019)..

Jing, J. et al. High-speed upper-airway imaging using full-range optical coherence tomography.J. Biomed. Opt.17, 110507 (2012)..

Li, Y. et al. Intravascular optical coherence tomography for characterization of atherosclerosis with a 1.7 micron swept-source laser.Sci. Rep.7, 14525 (2017)..

Choi, S. et al. Multifrequency-swept optical coherence microscopy for highspeed full-field tomographic vibrometry in biological tissues.Biomed. Opt. Express8, 608-621 (2017)..

Makita, S.&Yasuno, Y. Detection of local tissue alteration during retinal laser photocoagulation of ex vivo porcine eyes using phase-resolved optical coherence tomography.Biomed. Opt. Express8, 3067-3080 (2017)..

Zhu, J., He, X. D.&Chen, Z. P. Perspective: current challenges and solutions of Doppler optical coherence tomography and angiography for neuroimaging.APL Photonics3, 120902 (2018)..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰