Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

Isabel Barth; Donato Conteduca; Christopher Reardon; Steven Johnson; Thomas F. Krauss

doi:10.1038/s41377-020-0336-6

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Common-path interferometric label-free protein sensing with resonant dielectric nanostructures

Original Articles

- Common-path interferometric label-free protein sensing with resonant dielectric nanostructures
- Light: Science & Applications Vol. 9, Issue 4, Pages: 1009-1017(2020)
- Affiliations：
  
  1.Department of Physics, University of York, YO10 5DD York, UK
  2.Department of Electronic Engineering, University of York, YO10 5DD York, UK
- Author bio：
  
  Isabel Barth (isabel.barth@york.ac.uk)
- Funds：
- DOI：10.1038/s41377-020-0336-6
  CLC：
- Published：2020，
  
  Published Online：02 June 2020，
  
  Received：06 January 2020，
  
  Revised：14 May 2020，
  
  Accepted：22 May 2020
- Accepted：
Scan QR Code
Barth, I. et al. Common-path interferometric label-free protein sensing with resonant dielectric nanostructures. Light: Science & Applications, 9, 1009-1017 (2020).
DOI：

Barth, I. et al. Common-path interferometric label-free protein sensing with resonant dielectric nanostructures. Light: Science & Applications, 9, 1009-1017 (2020). DOI： 10.1038/s41377-020-0336-6.

摘要

Abstract

Research toward photonic biosensors for point-of-care applications and personalized medicine is driven by the need for high-sensitivity

low-cost

and reliable technology. Among the most sensitive modalities

interferometry offers particularly high performance

but typically lacks the required operational simplicity and robustness. Here

we introduce a common-path interferometric sensor based on guided-mode resonances to combine high performance with inherent stability. The sensor exploits the simultaneous excitation of two orthogonally polarized modes

and detects the relative phase change caused by biomolecular binding on the sensor surface. The wide dynamic range of the sensor

which is essential for fabrication and angle tolerance

as well as versatility

is controlled by integrating multiple

tuned structures in the field of view. This approach circumvents the trade-off between sensitivity and dynamic range

typical of other phase-sensitive modalities

without increasing complexity. Our sensor enables the challenging label-free detection of procalcitonin

a small protein (13 kDa) and biomarker for infection

at the clinically relevant concentration of 1 pg mL

−1

with a signal-to-noise ratio of 35. This result indicates the utility for an exemplary application in antibiotic guidance

and opens possibilities for detecting further clinically or environmentally relevant small molecules with an intrinsically simple and robust sensing modality.

关键词

Keywords

references

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