Engineering single-molecule fluorescence with asymmetric nano-antennas

Wenqi Zhao; Xiaochaoran Tian; Zhening Fang; Shiyi Xiao; Meng Qiu; Qiong He; Wei Feng; Fuyou Li; Yuanbo Zhang; Lei Zhou (phzhou@fudan.edu.cn) ZhouLei; Yan-Wen Tan

doi:10.1038/s41377-021-00522-9

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Engineering single-molecule fluorescence with asymmetric nano-antennas

Articles

- Engineering single-molecule fluorescence with asymmetric nano-antennas
- Light: Science & Applications Vol. 10, Issue 5, Pages: 858-866(2021)
- Affiliations：
  
  1.State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
  2.Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai 200444, China
  3.Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, Shanghai University, Shanghai 200444, China
  4.Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China
  5.Institute for Nanoelectronic Devices and Quantum Computing, Fudan University, Shanghai 200433, China
  6.Collaborative Innovation Center of Advanced Microstructures, Nanjing 210093, China
  7.Multiscale Research Institute of Complex Systems, Fudan University, Shanghai 200433, China
- Author bio：
  
  Lei Zhou (phzhou@fudan.edu.cn)
  Yan-Wen Tan (ywtan@fudan.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00522-9
  CLC：
- Published：31 May 2021，
  
  Published Online：14 April 2021，
  
  Received：18 October 2020，
  
  Revised：13 March 2021，
  
  Accepted：29 March 2021
- Accepted：
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Zhao, W. Q. et al. Engineering single-molecule fluorescence with asymmetric nano-antennas. Light: Science & Applications, 10, 858-866 (2021).
DOI：

Zhao, W. Q. et al. Engineering single-molecule fluorescence with asymmetric nano-antennas. Light: Science & Applications, 10, 858-866 (2021). DOI： 10.1038/s41377-021-00522-9.

摘要

Abstract

As a powerful tool for studying molecular dynamics in bioscience

single-molecule fluorescence detection provides dynamical information buried in ensemble experiments. Fluorescence in the near-infrared (NIR) is particularly useful because it offers higher signal-to-noise ratio and increased penetration depth in tissue compared with visible fluorescence. The low quantum yield of most NIR fluorophores

however

makes the detection of single-molecule fluorescence difficult. Here

we use asymmetric plasmonic nano-antenna to enhance the fluorescence intensity of AIEE1000

a typical NIR dye

by a factor up to 405. The asymmetric nano-antenna achieve such an enhancement mainly by increasing the quantum yield (to ~80%) rather than the local field

which degrades the molecules' photostability. Our coupled-mode-theory analysis reveals that the enhancements stem from resonance-matching between antenna and molecule and

more importantly

from optimizing the coupling between the near- and far-field modes with designer asymmetric structures. Our work provides a universal scheme for engineering single-molecule fluorescence in the near-infrared regime.

关键词

Keywords

references

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