Nanophotonics enhanced coverslip for phase imaging in biology

Lukas Wesemann; Jon Rickett; Jingchao Song; Jieqiong Lou; Elizabeth Hinde; Timothy J. Davis; Ann Roberts

doi:10.1038/s41377-021-00540-7

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Nanophotonics enhanced coverslip for phase imaging in biology

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- Nanophotonics enhanced coverslip for phase imaging in biology
- Light: Science & Applications Vol. 10, Issue 6, Pages: 957-962(2021)
- Affiliations：
  
  1.School of Physics, University of Melbourne, Melbourne, VIC, 3010 Australia
  2.ARC Centre of Excellence for Transformative Meta-Optical Systems, School of Physics, University of Melbourne, Melbourne, VIC, 3010 Australia
- Author bio：
  
  Lukas Wesemann (Lukas.wesemann@unimelb.edu.au)
  Ann Roberts (ann.roberts@unimelb.edu.au)
- Funds：
- DOI：10.1038/s41377-021-00540-7
  CLC：
- Published：30 June 2021，
  
  Published Online：08 May 2021，
  
  Received：20 November 2020，
  
  Revised：01 April 2021，
  
  Accepted：19 April 2021
- Accepted：
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Wesemann, L. et al. Nanophotonics enhanced coverslip for phase imaging in biology. Light: Science & Applications, 10, 957-962 (2021).
DOI：

Wesemann, L. et al. Nanophotonics enhanced coverslip for phase imaging in biology. Light: Science & Applications, 10, 957-962 (2021). DOI： 10.1038/s41377-021-00540-7.

摘要

Abstract

The ability to visualise transparent objects such as live cells is central to understanding biological processes. Here we experimentally demonstrate a novel nanostructured coverslip that converts phase information to high-contrast intensity images. This compact device enables real-time

all-optical generation of pseudo three-dimensional images of phase objects on transmission. We show that by placing unstained human cancer cells on the device

the internal structure within the cells can be clearly seen. Our research demonstrates the significant potential of nanophotonic devices for integration into compact imaging and medical diagnostic devices.

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references

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