Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model

Lechan Tao; Qi Liu; Fuli Zhang; Yuting Fu; Xi Zhu; Xiaofu Weng; Hongbin Han; Yong Huang; Yuanzhen Suo; Liang Chen; Xiaoling Gao; Xunbin Wei

doi:10.1038/s41377-021-00617-3

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Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model

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- Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model
- Light: Science & Applications Vol. 10, Issue 10, Pages: 1863-1876(2021)
- Affiliations：
  
  1.State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China
  2.Institute of Medical Technology, Peking University Health Science Center, Beijing, 100191, China
  3.Department of Radiology, Peking University Third Hospital, Beijing, 100191, China
  4.Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing, 100191, China
  5.Zhejiang Brainhealth Medical Technology Co., Ltd, Hangzhou, 314400, China
  6.Biomedical Pioneering Innovation Center, Peking University, Beijing, 100871, China
  7.School of Life Sciences, Peking University, Beijing, 100871, China
  8.Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China
  9.Tianqiao and Chrissy Chen Institute for Clinical Translational Research, Huashan Hospital, Shanghai, 200040, China
  10.Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
  11.Biomedical Engineering Department, Peking University, Beijing, 100081, China
  12.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China
- Author bio：
  
  Liang Chen (hschenliang@fudan.edu.cn)
  Xiaoling Gao (shellygao1@sjtu.edu.cn)
  Xunbin Wei (xwei01@sjtu.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00617-3
  CLC：
- Published：31 October 2021，
  
  Published Online：08 September 2021，
  
  Received：13 April 2021，
  
  Revised：29 July 2021，
  
  Accepted：17 August 2021
- Accepted：
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Tao, L. C. et al. Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model. Light: Science & Applications, 10, 1863-1876 (2021).
DOI：

Tao, L. C. et al. Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model. Light: Science & Applications, 10, 1863-1876 (2021). DOI： 10.1038/s41377-021-00617-3.

摘要

Abstract

Photobiomodulation

by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues

has been considered as a possible therapeutic strategy for Alzheimer's disease (AD)

while its specific mechanisms have remained elusive. Here

we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral β-amyloid (Aβ) burden

the hallmark of AD. The glial cells

including microglia and astrocytes

play important roles in Aβ clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with Aβ are sufficient to reduce Aβ load in AD mice. Moreover

1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβ clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD.

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references

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