Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

Lanhua Liu; Xuejun Zhang; Qian Zhu; Kaiwei Li; Yun Lu; Xiaohong Zhou; Tuan Guo

doi:10.1038/s41377-021-00618-2

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Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

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- Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs
- Light: Science & Applications Issue 10, Pages: 1849-1861(2021)
- Affiliations：
  
  1.State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing, 100084, China
  2.Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China
- Author bio：
  
  Xiaohong Zhou (xhzhou@mail.tsinghua.edu.cn)
  Tuan Guo (tuanguo@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00618-2
  CLC：
- Published：31 October 2021，
  
  Published Online：07 September 2021，
  
  Received：29 May 2021，
  
  Revised：14 August 2021，
  
  Accepted：17 August 2021
- Accepted：
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Liu, L. H. et al. Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs. Light: Science & Applications, 10, 1849-1861 (2021).
DOI：

Liu, L. H. et al. Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs. Light: Science & Applications, 10, 1849-1861 (2021). DOI： 10.1038/s41377-021-00618-2.

摘要

Abstract

The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of detecting endocrine disruptors. However

a long-lasting challenge unaddressed is how to achieve ultrahigh sensitive

continuous

and in situ measurement with a portable device for in-field and remote environmental monitoring. Here we demonstrate a simple-to-implement plasmonic optical fiber biosensing platform to achieve an improved light–matter interaction and advanced surface chemistry for ultrasensitive detection of endocrine disruptors. Our platform is based on a gold-coated highly tilted fiber Bragg grating that excites high-density narrow cladding mode spectral combs that overlap with the broad absorption of the surface plasmon for high accurac

y interrogation

hence enabling the ultrasensitive monitoring of refractive index changes at the fiber surface. Through the use of estrogen receptors as the model

we design an estradiol–streptavidin conjugate with the assistance of molecular dynamics

converting the specific recognition of environmental estrogens (EEs) by estrogen receptor into surface-based affinity bioassay for protein. The ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5 × 10

−3

ng ml

−1

estradiol equivalent concentration level

which is one order lower than the defined maximal E

level in drinking water set by the Japanese government. The capability to detect EEs down to nanogram per liter level is the lowest limit of detection for any estrogen receptor-based detection reported thus far. Its compact size

flexible shape

and remote operation capability open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-to-reach spaces

thereby having the potential to revolutionize environment and health monitoring.

关键词

Keywords

references

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