Perfecting and extending the near-infrared imaging window

Zhe Feng; Tao Tang; Tianxiang Wu; Xiaoming Yu; Yuhuang Zhang; Meng Wang; Junyan Zheng; Yanyun Ying; Siyi Chen; Jing Zhou; Xiaoxiao Fan; Dan Zhang; Shengliang Li; Mingxi Zhang; Jun Qian

doi:10.1038/s41377-021-00628-0

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Perfecting and extending the near-infrared imaging window

Articles

- Perfecting and extending the near-infrared imaging window
- Light: Science & Applications Vol. 10, Issue 10, Pages: 1949-1966(2021)
- Affiliations：
  
  1.State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, 310058, Hangzhou, China
  2.Intelligent Optics & Photonics Research Center, Jiaxing Institute of Zhejiang University, 314000, Jiaxing, Zhejiang Province, China
  3.State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 430070, Wuhan, China
  4.Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China
  5.College of Pharmaceutical Sciences, Soochow University, 215123, Suzhou, China
- Author bio：
  
  Mingxi Zhang (mxzhang@whut.edu.cn)
  Jun Qian (qianjun@zju.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00628-0
  CLC：
- Published：31 October 2021，
  
  Published Online：24 September 2021，
  
  Received：22 May 2021，
  
  Revised：30 August 2021，
  
  Accepted：31 August 2021
- Accepted：
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Feng, Z. et al. Perfecting and extending the near-infrared imaging window. Light: Science & Applications, 10, 1949-1966 (2021).
DOI：

Feng, Z. et al. Perfecting and extending the near-infrared imaging window. Light: Science & Applications, 10, 1949-1966 (2021). DOI： 10.1038/s41377-021-00628-0.

摘要

Abstract

In vivo fluorescence imaging in the second near-infrared window (NIR-Ⅱ) has been considered as a promising technique for visualizing mammals. However

the definition of the NIR-Ⅱ region and the mechanism accounting for the excellent performance still need to be perfected. Herein

we simulate the photon propagation in the NIR region (to 2340 nm)

confirm the positive contribution of moderate light absorption by water in intravital imaging and perfect the NIR-Ⅱ window as 900-1880 nm

where 1400-1500 and 1700-1880 nm are defined as NIR-Ⅱx and NIR-Ⅱc regions

respectively. Moreover

2080-2340 nm is newly proposed as the third near-infrared (NIR-Ⅲ) window

which is believed to provide the best imaging quality. The wide-field fluorescence microscopy in the brain is performed around the NIR-Ⅱx region

with excellent optical sectioning strength and the largest imaging depth of intravital NIR-Ⅱ fluorescence microscopy to date. We also propose 1400 nm long-pass detection in off-peak NIR-Ⅱ imaging whose performance exceeds that of NIR-Ⅱb imaging

using bright fluorophores with short emission wavelength.

关键词

Keywords

references

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