Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations

Peijun Tang; Mitchell A. Kirby; Nhan Le; Yuandong Li; Nicole Zeinstra; G. Nina Lu; Charles E. Murry; Ying Zheng; Ruikang K. Wang

doi:10.1038/s41377-021-00679-3

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Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations

Articles

- Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations
- Light: Science & Applications Vol. 10, Issue 12, Pages: 2455-2466(2021)
- Affiliations：
  
  1.Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA
  2.Department of Otolaryngology- Head and Neck Surgery, Facial Plastic and Reconstructive Surgery, University of Washington, Seattle, WA 98195, USA
  3.Department of Pathology, University of Washington, Seattle, WA 98109, USA
  4.Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA
  5.Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
  6.Department of Ophthalmology, University of Washington, Seattle, WA 98105, USA
- Author bio：
  
  Ruikang K. Wang (wangrk@uw.edu)
- Funds：
- DOI：10.1038/s41377-021-00679-3
  CLC：
- Published：31 December 2021，
  
  Published Online：24 November 2021，
  
  Received：28 June 2021，
  
  Revised：26 October 2021，
  
  Accepted：10 November 2021
- Accepted：
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Tang P.et al. Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations. Light: Science & Applications, 10, 2455-2466 (2021).
DOI：

Tang P.et al. Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations. Light: Science & Applications, 10, 2455-2466 (2021). DOI： 10.1038/s41377-021-00679-3.

摘要

Abstract

Collagen organization plays an important role in maintaining structural integrity and determining tissue function. Polarization-sensitive optical coherence tomography (PSOCT) is a promising noninvasive three-dimensional imaging tool for mapping collagen organization in vivo. While PSOCT systems with multiple polarization inputs have demonstrated the ability to visualize depth-resolved collagen organization

systems

which use a single input polarization state have not yet demonstrated sufficient reconstruction quality. Herein we describe a PSOCT based polarization state transmission model that reveals the depth-dependent polarization state evolution of light backscattered within a birefringent sample. Based on this model

we propose a polarization state tracing method that relies on a discrete differential geometric analysis of the evolution of the polarization state in depth along the Poincare sphere for depth-resolved birefringent imaging using only one single input polarization state. We demonstrate the ability of this method to visualize depth-resolved myocardial architecture in both healthy and infarcted rodent hearts (ex vivo) and collagen structures responsible for skin tension lines at various anatomical locations on the face of a healthy human volunteer (in vivo).

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references

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