Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy

Liyun Lin; Wen Pang; Xinyan Jiang; Shihui Ding; Xunbin Wei; Bobo Gu

doi:10.1038/s41377-021-00704-5

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Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy

Articles

- Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy
- Light: Science & Applications Vol. 11, Issue 3, Pages: 341-356(2022)
- Affiliations：
  
  1.Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China
  2.Biomedical Engineering Department, Peking University, Beijing, 100081, China
  3.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China
- Author bio：
  
  Xunbin Wei (xwei@bjmu.edu.cn)
  Bobo Gu (bobogu@sjtu.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00704-5
  CLC：
- Published：31 March 2022，
  
  Published Online：01 March 2022，
  
  Received：12 July 2021，
  
  Revised：10 December 2021，
  
  Accepted：25 December 2021
- Accepted：
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Lin, L. Y. et al. Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy. Light: Science & Applications, 11, 341-356 (2022).
DOI：

Lin, L. Y. et al. Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy. Light: Science & Applications, 11, 341-356 (2022). DOI： 10.1038/s41377-021-00704-5.

摘要

Abstract

Photodynamic therapy (PDT)

which utilizes light excite photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue

has attracted a great deal of attention in the last decades due to its unique advantages. However

the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment (TME). It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes. Herein

we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic anticancer therapy. Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME

which could be further amplified under light irradiation. Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS (hydroxyl radicals and singlet oxygen) generation efficiency

hypoxia relief

and glutathione depletion. Moreover

the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.

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references

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