A nanotheranostic agent based on Nd<sup>3+</sup>-doped YVO<sub>4</sub> with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma

Zhijia Lv; Longhai Jin; Yue Cao; Hao Zhang; Dongzhi Xue; Na Yin; Tianqi Zhang; Yinghui Wang; Jianhua Liu; Xiaogang Liu; Hongjie Zhang

doi:10.1038/s41377-022-00794-9

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A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma

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- A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma
- Light: Science & Applications Vol. 11, Issue 6, Pages: 1088-1097(2022)
- Affiliations：
  
  1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences, 130022, Changchun, China
  2.University of Science and Technology of China, 230026, Hefei, Anhui, China
  3.Ganjiang Innovation Academy, Chinese Academy of Sciences, 341000, Ganzhou, Jiangxi, China
  4.Department of Radiology, The Second Hospital of Jilin University, 130041, Changchun, China
  5.Department of Neurosurgery, The First Hospital of Jilin University, 130041, Changchun, China
  6.Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore
  7.Department of Chemistry, Tsinghua University, 100084, Beijing, China
- Author bio：
  
  Yinghui Wang (yhwang@ciac.ac.cn)
  Jianhua Liu (drliujh@yahoo.com)
  Hongjie Zhang (hongjie@ciac.ac.cn)
- Funds：
- DOI：10.1038/s41377-022-00794-9
  CLC：
- Published：30 June 2022，
  
  Published Online：29 April 2022，
  
  Received：22 December 2021，
  
  Revised：31 March 2022，
  
  Accepted：08 April 2022
- Accepted：
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Lv, Z. J. et al. A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma. Light: Science & Applications, 11, 1088-1097 (2022).
DOI：

Lv, Z. J. et al. A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma. Light: Science & Applications, 11, 1088-1097 (2022). DOI： 10.1038/s41377-022-00794-9.

摘要

Abstract

The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their high invasiveness and blood-brain barrier (BBB) obstruction. It is highly desirable to find a multifunctional agent with good BBB penetration for precise theranostics. Herei

we design and construct a core-shell structured nanotheranostic agent (YVO

: Nd

-HMME@MnO

-LF

marked as YHM) with YVO

: Nd

particles as the core and MnO

nanosheets as the shell. Sonosensitizer hematoporphyrinmonomethyl ether (HMME) and lactoferrin (LF) were further loaded and modified on the surface

giving it a good ability to cross the BBB

near-infrared fluorescence imaging in the second window (NIR-Ⅱ)/magnetic resonance imaging (MRI) bimodality

and highly efficient sonodynamic therapy (SDT) of orthotopic gliomas. The YVO

: Nd

(25%) core exhibited good NIR-Ⅱ fluorescence properties

enabling YHM to act as promising probes for NIR-Ⅱ fluorescence imaging of vessels and orthotopic gliomas. MnO

shell can not only provide O

in the tumor microenvironments (TME) to significantly improve the healing efficacy of SDT

but also release Mn

ions to achieve T

-weight MRI in situ. Non-invasive SDT can effectively restrain tumor growth. This work not only demonstrates that multifunctional YHM is promising for diagnosis and treatment of orthotopic glioma

but also provides insights into exploring the theranostic agents based on rare earth-doped yttrium vanadate nanoparticles.

关键词

Keywords

references

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A nanotheranostic agent based on Nd3+-doped YVO4 with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma

DOI：10.1038/s41377-022-00794-9

摘要

Abstract

关键词

Keywords

references

A nanotheranostic agent based on Nd³⁺-doped YVO₄ with blood-brain-barrier permeability for NIR-Ⅱ fluorescence imaging/magnetic resonance imaging and boosted sonodynamic therapy of orthotopic glioma