Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

Zheng Wei; Yawei Liu; Bo Li; Jingjing Li; Shuang Lu; Xiwen Xing; Kai Liu; Fan Wang; Hongjie Zhang

doi:10.1038/s41377-022-00864-y

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Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation

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- Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation
- Light: Science & Applications Vol. 11, Issue 8, Pages: 1667-1685(2022)
- Affiliations：
  
  1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
  2.School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China
  3.Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China
  4.Department of Chemistry, Tsinghua University, Beijing, 100084, China
- Author bio：
  
  Shuang Lu (slu@ciac.ac.cn)
  Xiwen Xing (xingxiwen@jnu.edu.cn)
  Fan Wang (wangfan@ciac.ac.cn)
- Funds：
- DOI：10.1038/s41377-022-00864-y
  CLC：
- Published：31 August 2022，
  
  Published Online：10 June 2022，
  
  Received：25 February 2022，
  
  Revised：13 May 2022，
  
  Accepted：25 May 2022
- Accepted：
Scan for full text
Wei, Z. et al. Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation. Light: Science & Applications, 11, 1667-1685 (2022).
DOI：

Wei, Z. et al. Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation. Light: Science & Applications, 11, 1667-1685 (2022). DOI： 10.1038/s41377-022-00864-y.

摘要

Abstract

Brain diseases

including tumors and neurodegenerative disorders

are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition

efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties

superior magnetism

and high X-ray absorption abilities

enabling high-resolution imaging of the brain through magnetic resonance imaging

computed tomography imaging

and fluorescence imaging technologies. In addition

rare-earth based materials can be used to detect

treat

and regulate of brain diseases through fine modulation of their structures and functions. Importantly

rare-earth based materials coupled with biomolecules such as antibodies

peptides

and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein

this review highlights the rational design and application of rare-earth based materials in brain imaging

therapy

monitoring

and neuromodulation. Furthermore

the development prospect of rare-earth based materials is briefly introduced.

关键词

Keywords

references

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