SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy

Linjia Li; Jin Yang; Jiahui Wei; Chunhuan Jiang; Zhuo Liu; Bai Yang; Bing Zhao; Wei Song

doi:10.1038/s41377-022-00968-5

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SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy

Original Articles

- SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy
- Light: Science & Applications Vol. 11, Issue 10, Pages: 2492-2502(2022)
- Affiliations：
  
  1.State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China
  2.Department of Vascular Surgery of China-Japan Union Hospital, Jilin University, Changchun, 130031, China
  3.College of Basic Medical Sciences, Jilin University, Changchun, 130021, China
  4.Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, 130062, China
  5.State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
- Author bio：
  
  Zhuo Liu (lzhuo@jlu.edu.cn)
  Bing Zhao (zhaob@jlu.edu.cn)
  Wei Song (weisong@jlu.edu.cn)
- Funds：
- DOI：10.1038/s41377-022-00968-5
  CLC：
- Published：31 October 2022，
  
  Published Online：30 September 2022，
  
  Received：10 March 2022，
  
  Revised：01 August 2022，
  
  Accepted：23 August 2022
- Accepted：
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Li, L. J. et al. SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy. Light: Science & Applications, 11, 2492-2502 (2022).
DOI：

Li, L. J. et al. SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic therapy. Light: Science & Applications, 11, 2492-2502 (2022). DOI： 10.1038/s41377-022-00968-5.

摘要

Abstract

Currently

artificial enzymes-based photodynamic therapy (PDT) is attractive due to its efficient capacity to change the immunosuppressive tumor microenvironment (TME). It is of great significance to study the therapeutic mechanism of novel artificial enzymes in TME through a monitoring strategy and improve the therapeutic effect. In this study

Au@carbon dots (Au@CDs) nanohybrids with a core-shell structure are synthesized

which not only exhibit tunable enzyme-mimicking activity under near-infrared (NIR) light

but also excellent surface-enhanced Raman scattering (SERS) properties. Therefore

Au@CDs show a good capability for monitoring NIR-photoinduced peroxidase-like catalytic processes via a SERS strategy in tumor. Moreover

the Au@CDs deplete glutathione with the cascade catalyzed reactions

thus elevating intratumor oxidative stress amplifying the reactive oxygen species damage based on the NIR-photoinduced enhanced peroxidase and glutathione oxidase-like activities

showing excellent and fast PDT therapeutic effect promoted by photothermal property in 3 min

finally leading to apoptosis in cancer cells. Through SERS monitoring

it is further found that after removing the NIR light source for 33 min

the reactive oxygen species (ROS) activity of the TME is counteracted and eliminated due to the presence of glutathione. This work presents a guidance to rationally design of artificial enzyme for ROS-involved therapeutic strategies and a new spectroscopic tool to evaluate the tumor catalytic therapy.

关键词

Keywords

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