Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision

Yueming Li; Ying Jiang; Lu Lan; Xiaowei Ge; Ran Cheng; Yuewei Zhan; Guo Chen; Linli Shi; Runyu Wang; Nan Zheng; Chen Yang; Ji-Xin Cheng

doi:10.1038/s41377-022-01004-2

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Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision

Original Articles

- Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision
- Light: Science & Applications Vol. 11, Issue 11, Pages: 2817-2831(2022)
- Affiliations：
  
  1.Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA
  2.Graduate Program for Neuroscience, Boston University, Boston, MA 02215, USA
  3.Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA
  4.Department of Chemistry, Boston University, Boston, MA 02215, USA
  5.Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
  6.Division of Materials Science and Engineering, Boston University, Boston, MA 02215, USA
  7.Present address: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
- Author bio：
  
  Chen Yang (cheyang@bu.edu)
  Ji-Xin Cheng (jxcheng@bu.edu)
- Funds：
- DOI：10.1038/s41377-022-01004-2
  CLC：
- Published：30 November 2022，
  
  Published Online：03 November 2022，
  
  Received：07 June 2022，
  
  Revised：29 September 2022，
  
  Accepted：07 October 2022
- Accepted：
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Li, Y. M. et al. Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision. Light: Science & Applications, 11, 2817-2831 (2022).
DOI：

Li, Y. M. et al. Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision. Light: Science & Applications, 11, 2817-2831 (2022). DOI： 10.1038/s41377-022-01004-2.

摘要

Abstract

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here

we report optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS is generated by a soft optoacoustic pad (SOAP) fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film. SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83 µm

which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound (tFUS). Here

we show effective OFUS neurostimulation in vitro with a single ultrasound cycle. We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo. An acoustic energy of 0.6 mJ/cm

four orders of magnitude less than that of tFUS

is sufficient for successful OFUS neurostimulation. OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision non-invasively.

关键词

Keywords

references

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