Controlled afterglow luminescent particles for photochemical tissue bonding

Seong-Jong Kim; Minji Choi; Guosong Hong; Sei Kwang Hahn

doi:10.1038/s41377-022-01011-3

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Controlled afterglow luminescent particles for photochemical tissue bonding

Original Articles

- Controlled afterglow luminescent particles for photochemical tissue bonding
- Light: Science & Applications Vol. 11, Issue 11, Pages: 2755-2765(2022)
- Affiliations：
  
  1.Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea
  2.Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA
- Author bio：
  
  Sei Kwang Hahn (skhanb@postech.ac.kr)
- Funds：
- DOI：10.1038/s41377-022-01011-3
  CLC：
- Published：30 November 2022，
  
  Published Online：27 October 2022，
  
  Received：02 May 2022，
  
  Revised：23 August 2022，
  
  Accepted：10 October 2022
- Accepted：
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Kim, S. J. et al. Controlled afterglow luminescent particles for photochemical tissue bonding. Light: Science & Applications, 11, 2755-2765 (2022).
DOI：

Kim, S. J. et al. Controlled afterglow luminescent particles for photochemical tissue bonding. Light: Science & Applications, 11, 2755-2765 (2022). DOI： 10.1038/s41377-022-01011-3.

摘要

Abstract

Upconversion materials (UCMs) have been developed to convert tissue-penetrating near-infrared (NIR) light into visible light. However

the low energy conversion efficiency of UCMs has limited their further biophotonic applications. Here

we developed controlled afterglow luminescent particles (ALPs) of ZnS: Ag

Co with strong and persistent green luminescence for photochemical tissue bonding (PTB). The co-doping of Ag

and Co

ions into ZnS: Ag

Co particles with the proper vacancy formation of host ions resulted in high luminescence intensity and long-term afterglow. In addition

the ALPs of ZnS: Ag

Co could be recharged rapidly under short ultraviolet (UV) irradiation

which effectively activated rose bengal (RB) in hyaluronate-RB (HA-RB) conjugates for the crosslinking of dissected collagen layers without additional light irradiation. The remarkable PTB of ZnS: Ag

Co particles with HA-RB conjugates was confirmed by in vitro collagen fibrillogenesis assay

in vivo animal wound closure rate analysis

and in vivo tensile strength evaluation of incised skin tissues. Taken together

we could confirm the feasibility of controlled ALPs for various biophotonic applications.

关键词

Keywords

references

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