Chemiluminescent carbon nanodots for dynamic and guided antibacteria

Jiang-Fan Han; Qing Lou; Zhong-Zheng Ding; Guang-Song Zheng; Qing-Chao Ni; Run-Wei Song; Kai-Kai Liu; Jin-Hao Zang; Lin Dong; Cheng-Long Shen; Chong-Xin Shan

doi:10.1038/s41377-023-01149-8

Go to Nature Website

Your Location：

Home >

Browse articles >

Chemiluminescent carbon nanodots for dynamic and guided antibacteria

Original Articles

- Chemiluminescent carbon nanodots for dynamic and guided antibacteria
- Light: Science & Applications Vol. 12, Issue 5, Pages: 915-927(2023)
- Affiliations：
  
  Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China
- Author bio：
  
  Qing Lou (louqing1986@zzu.edu.cn)
  Cheng-Long Shen (phyclshen@zzu.edu.cn)
  Chong-Xin Shan (cxshan@zzu.edu.cn)
- Funds：
- DOI：10.1038/s41377-023-01149-8
  CLC：
- Published：31 May 2023，
  
  Published Online：4 May 2023，
  
  Received：20 December 2022，
  
  Revised：2 April 2023，
  
  Accepted：2 April 2023
Scan for full text
Han, J. F. et al. Chemiluminescent carbon nanodots for dynamic and guided antibacteria. Light: Science & Applications, 12, 915-927 (2023).
DOI：

Han, J. F. et al. Chemiluminescent carbon nanodots for dynamic and guided antibacteria. Light: Science & Applications, 12, 915-927 (2023). DOI： 10.1038/s41377-023-01149-8.

摘要

Abstract

Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria. Image-guided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections. Herein

a chemiluminescence (CL)-dynamic/guided antibacteria (CDGA) with multiple reactive oxygen species (ROS) generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots (CDs) and peroxalate as CL fuels. Mechanistically

hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate

enabling bacterial induced inflammation imaging. Meanwhile

type Ⅰ/Ⅱ photochemical ROS production and type Ⅲ ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently. The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model. The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria

and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance

whose sterilizing rate is up to 99.99%.

关键词

Keywords

references

Zhao,W.B.etal.Near-infraredcarbonnanodotsforeffectiveidentificationandinactivationofGram-positivebacteria.Nano Res.15,1699–1708(2022)..

Jia,Q.Y.etal.Rejuvenatedphotodynamictherapyforbacterialinfections.Adv. Healthc. Mater.8,1900608(2019)..

Li,X.S.etal.Innovativestrategiesforhypoxic-tumorphotodynamictherapy.Angew. Chem. Int. Ed.57,11522–11531(2018)..

Yuan,H.X.etal.Chemicalmolecule-inducedlight-activatedsystemforanticancerandantifungalactivities.J. Am. Chem. Soc.134,13184–13187(2012)..

Hsu,C.Y.etal.Bioluminescenceresonanceenergytransferusingluciferase-immobilizedquantumdotsforself-illuminatedphotodynamictherapy.Biomaterials34,1204–1212(2013)..

Liu,S.S.etal.Electrochemiluminescenceforelectric-drivenantibacterialtherapeutics.J. Am. Chem. Soc.140,2284–2291(2018)..

Chen,M.M.etal.Singlecellimagingofelectrochemiluminescence-drivenphotodynamictherapy.Angew. Chem. Int. Ed.61,e202117401(2022)..

Shen,C.L.etal.Chemiluminescentcarbondots:synthesis,properties,andapplications.Nano Today35,100954(2020)..

Huang,J.S.etal.Chemiluminescentprobeswithlong-lastinghighbrightnessforinvivoimagingofneutrophils.Angew. Chem. Int. Ed.61,e202203235(2022)..

Yu,Z.Z.etal.Abiomimeticnanoreactorforsynergisticchemiexcitedphotodynamictherapyandstarvationtherapyagainsttumormetastasis.Nat. Commun.9,5044(2018)..

Mao,D.etal.Chemiluminescence-guidedcancertherapyusingachemiexcitedphotosensitizer.Chem3,991–1007(2017)..

Lu,C.etal.Light-freegenerationofsingletoxygenthroughmanganese-thiophenenanosystemsforpH-responsivechemiluminescenceimagingandtumortherapy.Chem6,2314–2334(2020)..

Yang,N.etal.Infectionmicroenvironment-activatednanoparticlesforNIR-Ⅱphotoacousticimaging-guidedphotothermal/chemodynamicsynergisticanti-infectivetherapy.Biomaterials275,120918(2021)..

Liu,Z.X.etal.AIE-activeluminogensashighlyefficientfree-radicalROSphotogeneratorforimage-guidedphotodynamictherapy.Chem. Sci.13,3599–3608(2022)..

Ding,D.&Tang,B.Z.Advancesinimprovinghealthcarewithaggregation-inducedemission.Adv. Healthc. Mater.10,2102499(2021)..

Zhang,P.etal.Rationaldesignofahigh-performancequinoxalinone-basedAIEphotosensitizerforimage-guidedphotodynamictherapy.ACS Appl. Mater. Interfaces12,42551–42557(2020)..

Liu,B.Q.etal.Highlyefficientfar-red/NIR-absorbingneutralIr(Ⅲ)complexmicellesforpotentphotodynamic/photothermaltherapy.Adv. Mater.33,2100795(2021)..

Jeon,J.etal.Chemiluminescenceresonanceenergytransfer-basednanoparticlesforquantumyield-enhancedcancerphototheranostics.Sci. Adv.6,eaaz840(2020)..

Zhuang,W.H.etal.Multifunctionaltwo-photonAIEluminogensforhighlymitochondria-specificbioimagingandefficientphotodynamictherapy.ACS Appl. Mater. Interfaces11,20715–20724(2019)..

Zhang,D.D.etal.Mitochondrialspecificphotodynamictherapybyrare-earthnanoparticlesmediatednear-infraredgraphenequantumdots.Biomaterials153,14–26(2018)..

Song,Q.etal.Efficientcascaderesonanceenergytransferindynamicnanoassemblyforintensiveandlong-lastingmulticolorchemiluminescence.ACS Nano14,3696–3702(2020)..

He,C.etal.Thesyntheticstrategies,photoluminescencemechanismsandpromisingapplicationsofcarbondots:currentstateandfutureperspective.Carbon186,91–127(2022)..

Nguyen,H.A.etal.Unravelingthefluorescencemechanismofcarbondotswithsub-single-particleresolution.ACS Nano14,6127–6137(2020)..

Liu,X.etal.EndogenousNO-releasingcarbonnanodotsfortumor-specificgastherapy.Acta Biomater.136,485–494(2021)..

Wang,B.G.etal.Ionicliquidcappedcarbondotsasahigh-performancefriction-reducingandantiwearadditiveforpoly(ethyleneglycol).J. Mater. Chem. A4,7257–7265(2016)..

Song,Y.etal.Drug-derivedbrightandcolor-tunableN-dopedcarbondotsforcellimagingandsensitivedetectionofFe3+inlivingcells.ACS Appl. Mater. Interfaces9,7399–7405(2017)..

Hua,X.W.etal.Nucleolus-targetedredemissivecarbondotswithpolarity-sensitiveandexcitation-independentfluorescenceemission:high-resolutioncellimagingandinvivotracking.ACS Appl. Mater. Interfaces11,32647–32658(2019)..

Shen,C.L.etal.Near-infraredchemiluminescentcarbonnanodotsandtheirapplicationinreactiveoxygenspeciesbioimaging.Adv. Sci.7,1903525(2020)..

Mandal,S.etal.Bovineserumalbuminamplifiedreactiveoxygenspeciesgenerationfromanthrarufin-derivedcarbondotandconcomitantnanoassemblyforcombinationantibiotic-photodynamictherapyapplication.ACS Appl. Mater. Interfaces11,33273–33284(2019)..

Shen,C.L.etal.Near‐infraredchemiluminescentcarbonnanogelsforoncologyimagingandtherapy.SmartMat3,269–285(2022)..

Yao,Q.C.etal.Theconceptandexamplesoftype-Ⅲphotosensitizersforcancerphotodynamictherapy.Chem8,197–209(2022)..

Mu,X.Y.etal.Anoligomericsemiconductingnanozymewithultrafastelectrontransfersalleviatesacutebraininjury.Sci. Adv.7,eabk1210(2021)..

Shen,C.L.etal.Brightandmulticolorchemiluminescentcarbonnanodotsforadvancedinformationencryption.Adv. Sci.6,1802331(2019)..

Liu,J.J.etal.Deepredemissivecarbonizedpolymerdotswithunprecedentednarrowfullwidthathalfmaximum.Adv. Mater.32,1906641(2020)..

Di,J.etal.Ultrathin2Dphotocatalysts:electronic-structuretailoring,hybridization,andapplications.Adv. Mater.30,1704548(2018)..

Holá,K.etal.Graphiticnitrogentriggersredfluorescenceincarbondots.ACS Nano11,12402–12410(2017)..

Bao,X.etal.Invivotheranosticswithnear-infrared-emittingcarbondots-highlyefficientphotothermaltherapybasedonpassivetargetingafterintravenousadministration.Light Sci. Appl.7,91(2018)..

Wang,L.etal.Full-colorfluorescentcarbonquantumdots.Sci. Adv.6,eabb6772(2020)..

Miao,X.etal.Synthesisofcarbondotswithmultiplecoloremissionbycontrolledgraphitizationandsurfacefunctionalization.Adv. Mater.30,1704740(2018)..

Li,D.etal.Near-infraredexcitation/emissionandmultiphoton-inducedfluorescenceofcarbondots.Adv. Mater.30,1705913(2018)..

Zhang,Y.Q.etal.Solid-statefluorescentcarbondotswithaggregation-inducedyellowemissionforwhitelight-emittingdiodeswithhighluminousefficiencies.ACS Appl. Mater. Interfaces11,24395–24403(2019)..

Wang,L.W.etal.Anall-organicsemiconductorC3N4/PDINHheterostructurewithadvancedantibacterialphotocatalytictherapyactivity.Adv. Mater.31,1901965(2019)..

Zhen,X.etal.Intraparticleenergylevelalignmentofsemiconductingpolymernanoparticlestoamplifychemiluminescenceforultrasensitiveinvivoimagingofreactiveoxygenspecies.ACS Nano10,6400–6409(2016)..

Liang,Y.C.etal.Lifetime-engineeredcarbonnanodotsfortimedivisionduplexing.Adv. Sci.8,2003433(2021)..

Chen,J.etal.TailoredhydrogeldeliveringniobiumcarbideboostsROS-scavengingandantimicrobialactivitiesfordiabeticwoundhealing.Small18,2201300(2022)..

Huang,H.H.etal.LEDirradiationofhalogen/nitrogen-dopedpolymericgraphenequantumdotstriggersthephotodynamicinactivationofbacteriaininfectedwounds.Carbon174,710–722(2021)..

Augusto,F.A.etal.Efficiencyofelectrontransferinitiatedchemiluminescence.Photochem. Photobiol.89,1299–1317(2013)..

Malone,M.&Schultz,G.Challengesinthediagnosisandmanagementofwoundinfection.Br. J. Dermatol.187,159–166(2022)..

Jansen,K.U.,Knirsch,C.&Anderson,A.S.Theroleofvaccinesinpreventingbacterialantimicrobialresistance.Nat. Med.24,10–19(2018)..

Zhao,C.F.etal.Quaternizedcarbonquantumdotswithbroad-spectrumantibacterialactivityforthetreatmentofwoundsinfectedwithmixedbacteria.Acta Biomater.138,528–544(2022)..

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰