A whispering-gallery scanning microprobe for Raman spectroscopy and imaging

Wenbo Mao; Yihang Li; Xuefeng Jiang; Zhiwen Liu; Lan Yang

doi:10.1038/s41377-023-01276-2

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A whispering-gallery scanning microprobe for Raman spectroscopy and imaging

Original Articles

- A whispering-gallery scanning microprobe for Raman spectroscopy and imaging
- Light: Science & Applications Vol. 12, Issue 11, Pages: 2402-2410(2023)
- Affiliations：
  
  1.Department of Electrical and Systems Engineering, Washington University, St Louis, MO 63130, USA
  2.Department of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, USA
- Author bio：
  
  Lan Yang (yang@seas.wustl.edu)
- Funds：
- DOI：10.1038/s41377-023-01276-2
  CLC：
- Published：30 November 2023，
  
  Published Online：05 October 2023，
  
  Received：10 March 2023，
  
  Revised：19 August 2023，
  
  Accepted：28 August 2023
- Accepted：
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Mao, W. B. et al. A whispering-gallery scanning microprobe for Raman spectroscopy and imaging. Light: Science & Applications, 12, 2402-2410 (2023).
DOI：

Mao, W. B. et al. A whispering-gallery scanning microprobe for Raman spectroscopy and imaging. Light: Science & Applications, 12, 2402-2410 (2023). DOI： 10.1038/s41377-023-01276-2.

摘要

Abstract

Optical whispering-gallery-mode microsensors are a promising platform for many applications

such as biomedical monitoring

magnetic sensing

and vibration detection. However

like many other micro/nanosensors

they cannot simultaneously have two critical properties – ultrahigh sensitivity and large detection area

which are desired for most sensing applications. Here

we report a novel scanning whispering-gallery-mode microprobe optimized for both features and demonstrate enhanced Raman spectroscopy

providing high-specificity information on molecular fingerprints that are important for numerous sensing applications. Combining the superiorities of whispering-gallery modes and nanoplasmonics

the microprobe exhibits a two-orders-of-magnitude sensitivity improvement over traditional plasmonics-only enhancement; this leads to molecular detection demonstrated with stronger target signals but less optical power required than surface-enhanced-Raman-spectroscopy substrates. Furthermore

the scanning microprobe greatly expands the effective detection area and realizes two-dimensional micron-resolution Raman imaging of molecular distribution. The versatile and ultrasensitive scanning microprobe configuration will thus benefit material characterization

chemical imaging

and quantum-enhanced sensing.

关键词

Keywords

references

Jiang, X. F. et al. Whispering-Gallery Sensors.Matter3, 371–392 (2020)..

Yu, D. S. et al. Whispering-gallery-mode sensors for biological and physical sensing.Nat. Rev. Methods Prim.1, 83 (2021)..

He, L. N., Özdemir, Ş. K.&Yang, L. Whispering gallery microcavity lasers.Laser Photon. Rev.7, 60–82 (2013)..

Toropov, N. et al. Review of biosensing with whispering-gallery mode lasers.Light Sci. Appl.10, 42, https://doi.org/10.1038/s41377-021-00471-3 (2021)..

Lin, G. P., Coillet, A.&Chembo, Y. K. Nonlinear photonics with high-Qwhispering-gallery-mode resonators.Adv. Opt. Photon.9, 828–890 (2017)..

Vollmer, F., Arnold, S.&Keng, D. Single virus detection from the reactive shift of a whispering-gallery mode.Proc. Natl Acad. Sci. USA105, 20701–20704 (2008)..

Zhu, J. G. et al. On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Qmicroresonator.Nat. Photon.4, 46–49 (2010)..

He, L. N. et al. Detecting single viruses and nanoparticles using whispering gallery microlasers.Nat. Nanotechnol.6, 428–432 (2011)..

Shao, L. B. et al. Detection of single nanoparticles and lentiviruses using microcavity resonance broadening.Adv. Mater.25, 5616–5620 (2013)..

Dantham, V. R. et al. Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity.Nano Lett.13, 3347–3351 (2013)..

Baaske, M. D., Foreman, M. R.&Vollmer, F. Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform.Nat. Nanotechnol.9, 933–939 (2014)..

Baaske, M. D.&Vollmer, F. Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution.Nat. Photon.10, 733–739 (2016)..

Chen, W. J. et al. Exceptional points enhance sensing in an optical microcavity.Nature548, 192–196 (2017)..

Yu, X. C. et al. Single-molecule optofluidic microsensor with interfacewhispering gallery modes.Proc. Natl Acad. Sci. USA119, e2108678119, https://doi.org/10.1073/pnas.2108678119 (2022)..

Shen, B. Q. et al. Detection of single nanoparticles using the dissipative interaction in a high-Qmicrocavity.Phys. Rev. Appl.5, 024011 (2016)..

Gavartin, E., Verlot, P.&Kippenberg, T. J. A hybrid on-chip optomechanical transducer for ultrasensitive force measurements.Nat. Nanotechnol.7, 509–514 (2012)..

Zhang, J. et al. Optomechanical dissipative solitons.Nature600, 75–80 (2021)..

Xu, X. Y. et al. Wireless whispering-gallery-mode sensor for thermal sensing and aerial mapping.Light Sci. Appl.7, 62 (2018)..

Liao, J.&Yang, L. Optical whispering-gallery mode barcodes for high-precision and wide-range temperature measurements.Light Sci. Appl.10, 32, https://doi.org/10.1038/s41377-021-00472-2 (2021)..

Huang, S. H. et al. Surface-enhanced Raman scattering on dielectric microspheres with whispering gallery mode resonance.Photon. Res.6, 346–356 (2018)..

Shen, X. Q. et al. Raman laser from an optical resonator with a grafted single-molecule monolayer.Nat. Photon.14, 95–101 (2020)..

Heylman, K. D. et al. Optical microresonators as single-particle absorption spectrometers.Nat. Photon.10, 788–795 (2016)..

Kauranen, M.&Zayats, A. V. Nonlinear plasmonics.Nat. Photon.6, 737–748 (2012)..

Tame, M. S. et al. Quantum plasmonics.Nat. Phys.9, 329–340 (2013)..

Ding, S. Y. et al. Nanostructure-based plasmon-enhanced Raman spectroscopy for surface analysis of materials. Nat. Rev. Mater. 1, 16021 (2016). https://doi.org/10.1038/natrevmats.2016.21.

Wang, X. et al. Fundamental understanding and applications of plasmon-enhanced Raman spectroscopy.Nat. Rev. Phys.2, 253–271 (2020)..

Han, X. X. et al. Surface-enhanced Raman spectroscopy.Nat. Rev. Methods Prim.1, 87, https://doi.org/10.1038/s43586-021-00083-6 (2021)..

Schwab, L. et al. Very-high-frequency probes for atomic force microscopy with silicon optomechanics.Microsyst. Nanoeng.8, 32, https://doi.org/10.1038/s41378-022-00364-4 (2022)..

Freudiger, C. W. et al. Label-free biomedical imaging with high sensitivity by stimulated raman scattering microscopy.Science322, 1857–1861 (2008)..

Casacio, C. A. et al. Quantum-enhanced nonlinear microscopy.Nature594, 201–206 (2021)..

Yang, M. W. et al. The application of coffee-ring effect in analytical chemistry.TrAC Trends in Analytical.Chemistry157, 116752 (2022)..

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