Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair

Liping Wang; Nicholas J. Long; Lihua Li; Yao Lu; Mei Li; Jiangkun Cao; Yu Zhang; Qinyuan Zhang; Shanhui Xu; Zhongmin Yang; Chuanbin Mao; Mingying Peng

doi:10.1038/s41377-018-0007-z

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Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair

Original Articles

- Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair
- Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair
- LSA 2018年7卷第4期页码：52-64
- Affiliations：
  
  1.The State Key Laboratory of Luminescent Materials and Devices, Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices, Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Engineering, South China University of Technology, 510641 Guangzhou, China
  2.Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK
  3.Guangdong Key Lab of Orthopedic Technology and Implant Materials, Department of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, 510010 Guangzhou, China
  4.Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK 73072, USA
  5.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
- Author bio：
  
  Mingying Peng (pengmingying@scut.edu.cn)
- Funds：
- DOI：10.1038/s41377-018-0007-z
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-05-18，
  
  收稿日期：2017-12-05，
  
  修回日期：2018-01-31，
  
  录用日期：2018-02-01
- Accepted：
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Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair[J]. LSA, 2018,7(4):52-64.

Wang, L. P. et al. Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair. Light: Science & Applications, 7, 52-64 (2018).
Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair[J]. LSA, 2018,7(4):52-64. DOI： 10.1038/s41377-018-0007-z.

Wang, L. P. et al. Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair. Light: Science & Applications, 7, 52-64 (2018). DOI： 10.1038/s41377-018-0007-z.

摘要

Abstract

Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations

such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair; it is very challenging to combine these functions into a material. Herein

we report the first photothermal (PT) effect in bismuth (Bi)-doped glasses. On the basis of this discovery

we have developed a new type of Bi-doped bioactive glass that integrates both functions

thus reducing the number of treatment cycles. We demonstrate that Bi-doped bioglasses (BGs) provide high PT efficiency

potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization. The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence (PL) or depolymerizing glass networks. In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation

differentiation

and mineralization. Upon illumination with near-infrared (NIR) light

the bioglass (BG) can efficiently kill bone tumor cells

as demonstrated via in vitro and in vivo experiments. This indicates excellent potential for the integration of multiple functions within the new materials

which will aid in the development and application of novel biomaterials.

关键词

Keywords

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