Add-on plasmonic patch as a universal fluorescence enhancer

Jingyi Luan; Jeremiah J. Morrissey; Zheyu Wang; Hamed Gholami Derami; Keng-Ku Liu; Sisi Cao; Qisheng Jiang; Congzhou Wang; Evan D. Kharasch; Rajesh R. Naik; Srikanth Singamaneni

doi:10.1038/s41377-018-0027-8

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Add-on plasmonic patch as a universal fluorescence enhancer

Original Articles

- Add-on plasmonic patch as a universal fluorescence enhancer
- Add-on plasmonic patch as a universal fluorescence enhancer
- LSA 2018年7卷第4期页码：237-249
- Affiliations：
  
  1.Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, St Louis, MO 63130, USA
  2.Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA
  3.Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA
  4.Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO 63110, USA
  5.The Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, USA
  6.711th Human Performance Wing, Air Force Research Laboratory, WrightPatterson Air Force Base, Dayton, OH 45433, USA
- Author bio：
  
  Rajesh R. Naik (rajesh.naik@us.af.mil)
  Srikanth Singamaneni (singamaneni@wustl.edu)
- Funds：
- DOI：10.1038/s41377-018-0027-8
  中图分类号：
- 纸质出版日期：2018，
  
  网络出版日期：2018-07-04，
  
  收稿日期：2017-11-19，
  
  修回日期：2018-04-09，
  
  录用日期：2018-04-25
- Accepted：
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Add-on plasmonic patch as a universal fluorescence enhancer[J]. LSA, 2018,7(4):237-249.

Luan, J. Y. et al. Add-on plasmonic patch as a universal fluorescence enhancer. Light: Science & Applications, 7, 237-249 (2018).
Add-on plasmonic patch as a universal fluorescence enhancer[J]. LSA, 2018,7(4):237-249. DOI： 10.1038/s41377-018-0027-8.

Luan, J. Y. et al. Add-on plasmonic patch as a universal fluorescence enhancer. Light: Science & Applications, 7, 237-249 (2018). DOI： 10.1038/s41377-018-0027-8.

摘要

Abstract

Fluorescence-based techniques are the cornerstone of modern biomedical optics

with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However

the weakness of the fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image

detect

and quantify biological species with low abundance. Here

we report a simple and universal method based on a flexible and conformal elastomeric film with adsorbed plasmonic nanostructures

which we term a "plasmonic patch

" that provides large (up to 100-fold) and uniform fluorescence enhancement on a variety of surfaces through simple transfer of the plasmonic patch to the surface. We demonstrate the applications of the plasmonic patch in improving the sensitivity and limit of detection (by more than 100 times) of fluorescence-based immunoassays implemented in microtiter plates and in microarray format. The novel fluorescence enhancement approach presented here represents a disease

biomarker

and application agnostic ubiquitously applicable fundamental and enabling technology to immediately improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner

without changing the original procedures of the existing techniques.

关键词

Keywords

references

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