Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography

Rongrong Liu; James A. Winkelmann; Graham Spicer; Yunxiao Zhu; Aya Eid; Guillermo A. Ameer; Vadim Backman; Ji Yi

doi:10.1038/s41377-018-0057-2

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Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography

Original Articles

- Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography
- Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography
- 光：科学与应用 2018年7卷第5期页码：542-554
- Affiliations：
  
  1.Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA
  2.Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, 60208, USA
  3.Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA
- Author bio：
  
  Ji Yi (jiyi@bu.edu)
- Funds：
- DOI：10.1038/s41377-018-0057-2
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Rongrong Liu, James A. Winkelmann, Graham Spicer, 等. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography[J]. 光：科学与应用, 2018,7(5):542-554.

Liu, R. R. et al. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography. Light: Science & Applications, 5, 542-554 (2018).
Rongrong Liu, James A. Winkelmann, Graham Spicer, 等. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography[J]. 光：科学与应用, 2018,7(5):542-554. DOI： 10.1038/s41377-018-0057-2.

Liu, R. R. et al. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography. Light: Science & Applications, 5, 542-554 (2018). DOI： 10.1038/s41377-018-0057-2.

摘要

Abstract

Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms. However, capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo. Here we demonstrate a novel optical imaging system, dual-band dual-scan inverse spectroscopic optical coherence tomography (D2-ISOCT), that, for the first time, can simultaneously obtain the following metrics in vivo using endogenous contrast: (1) capillary-level oxygen saturation and arteriolar-level blood flow rates, oxygen delivery rates, and oxygen metabolic rates; (2) spatial characteristics of tissue structures at length scales down to 30 nm; and (3) morphological images up to 2 mm in depth. To illustrate the capabilities of D2-ISOCT, we monitored alterations to capillaries and the surrounding pericapillary tissue (tissue between the capillaries) in the healing response of a mouse ear wound model. The obtained microvascular and ultrastructural metrics corroborated well with each other, showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool.

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references

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