Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles
Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles
- 光：科学与应用 2018年7卷第6期 页码：988-1000
- Affiliations：
1.NeuroTechnology Center, Department of Biological Sciences, Columbia University, New York, NY, 10027, USA
2.Van der Waals–Zeeman Institute, University of Amsterdam, 1098 XH, Amsterdam, Netherlands
3.Present address: Laboratori de Fisiologia Molecular, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
- Author bio：
Wieteke Boer (w.deboer@nwo.nl)
Jan J. Hirtz (hirtz@bio.uni-kl.de)
- Funds：
DOI：10.1038/s41377-018-0103-0
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Wieteke D. A. M. de Boer, Jan J. Hirtz, Antonio Capretti, 等. Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles[J]. 光：科学与应用, 2018,7(6):988-1000.
Boer, W. D. A. M. D.et al. Neuronal photoactivation through secondharmonic near-infrared absorption by gold nanoparticles. Light: Science & Applications, 7, 988-1000 (2018).
Wieteke D. A. M. de Boer, Jan J. Hirtz, Antonio Capretti, 等. Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles[J]. 光：科学与应用, 2018,7(6):988-1000. DOI： 10.1038/s41377-018-0103-0.
Boer, W. D. A. M. D.et al. Neuronal photoactivation through secondharmonic near-infrared absorption by gold nanoparticles. Light: Science & Applications, 7, 988-1000 (2018). DOI： 10.1038/s41377-018-0103-0.
摘要
Abstract
Optical activation of neurons requires genetic manipulation or the use of chemical photoactivators with undesirable side effects. As a solution to these disadvantages, here, we demonstrate optically evoked neuronal activity in mouse cortical neurons in acute slices and in vivo by nonlinear excitation of gold nanoparticles. In addition, we use this approach to stimulate individual epitheliomuscular cells and evoke body contractions in,Hydra vulgaris,. To achieve this, we use a low-power pulsed near-infrared excitation at the double-wavelength of the plasmon resonance of gold nanoparticles, which enables optical sectioning and allows for high spatial precision and large penetration depth. The effect is explained by second-harmonic Mie scattering, demonstrating light absorption by a second-order nonlinear process, which enables photothermal stimulation of the cells. Our approach also minimizes photodamage, demonstrating a major advancement towards precise and harmless photoactivation for neuroscience and human therapeutics.
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references
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