Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

James A. Winkelmann; Aya Eid; Graham Spicer; Luay M. Almassalha; The-Quyen Nguyen; Vadim Backman

doi:10.1038/s41377-018-0117-7

Go to Nature Website

Your Location：

Home >

Browse articles >

Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

Letters

- Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
- Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging
- LSA 2019年8卷第1期页码：13-21
- Affiliations：
  
  1.Department of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA
  2.Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, 60208, USA
- Author bio：
  
  Vadim Backman (v-backman@northwestern.edu)
- Funds：
- DOI：10.1038/s41377-018-0117-7
  中图分类号：
- 纸质出版日期：2019，
  
  网络出版日期：2019-01-16，
  
  收稿日期：2018-06-25，
  
  修回日期：2018-12-14，
  
  录用日期：2018-12-15
- Accepted：
Scan QR Code
Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging[J]. LSA, 2019,8(1):13-21.

Winkelmann, J. A. et al. Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging. Light: Science & Applications, 8, 13-21 (2019).
Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging[J]. LSA, 2019,8(1):13-21. DOI： 10.1038/s41377-018-0117-7.

Winkelmann, J. A. et al. Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging. Light: Science & Applications, 8, 13-21 (2019). DOI： 10.1038/s41377-018-0117-7.

摘要

Abstract

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method

which enables lymphatic vessel

blood

and tissue discrimination.

关键词

Keywords

references

Huang, D. et al. Optical coherence tomography.Science254, 1178-1181 (1991)..

Robles, F. E., Wilson, C., Grant, G.&Wax, A. Molecular imaging true-colour spectroscopic optical coherence tomography.Nat. Photonics5, 744-747 (2011)..

Chen, C. L.&Wang, R. K. Optical coherence tomography based angiography [Invited].Biomed. Opt. Express8, 1056-1082 (2017)..

Yi, J. et al. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography.J. Biomed. Opt.19, 036013 (2014)..

Chen, Z. P. et al. Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography.Opt. Lett.22, 1119-1121 (1997)..

Leitgeb, R. A. et al. Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography.Opt. Express11, 3116-3121 (2003)..

Barton, J. K.&Stromski, S. Flow measurement without phase information in optical coherence tomography images.Opt. Express13, 5234-5239 (2005)..

Fingler, J., Schwartz, D., Yang, C.&Fraser, S. E. Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography.Opt. Express15, 12636-12653 (2007)..

Makita, S., Hong, Y., Yamanari, M., Yatagai, T.&Yasuno, Y. Optical coherence angiography.Opt. Express14, 7821-7840 (2006)..

Fingler, J., Zawadzki, R. J., Werner, J. S., Schwartz, D.&Fraser, S. E. Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique.Opt. Express17, 22190-22200 (2009)..

Zhu, D., Wang, J., Zhi, Z. W., Wen, X.&Luo, Q. M. Imaging dermal blood flow through the intact rat skin with an optical clearing method.J. Biomed. Opt.15, 026008 (2010)..

Spaide, R. F., Fujimoto, J. G.&Waheed, N. K. Image artifacts in optical coherence tomography angiography.Retina35, 2163-2180 (2015)..

Robles, F. E., Chowdhury, S.&Wax, A. Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics.Biomed. Opt. Express1, 310-317 (2010)..

Li, Y. L., Seekell, K., Yuan, H., Robles, F. E.&Wax, A. Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography.Biomed. Opt. Express3, 1914-1923 (2012)..

Chong, S. P., Merkle, C. W., Leahy, C., Radhakrishnan, H.&Srinivasan, V. J. Quantitative microvascular hemoglobin mapping using visible light spectroscopic optical coherence tomography.Biomed. Opt. Express6, 1429-1450 (2015)..

Pi, S. H. et al. Automated spectroscopic retinal oximetry with visible-light optical coherence tomography.Biomed. Opt. Express9, 2056-2067 (2018)..

Chen, S., Yi, J.&Zhang, H. F. Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography.Biomed. Opt. Express6, 2840-2853 (2015)..

Chen, S. Y. et al. Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography.Biomed. Opt. Express7, 3377-3389 (2016)..

Yi, J. et al. Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation.Light Sci. Appl.4, e334 (2015)..

Liu, R. R. et al. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography.Light Sci. Appl.7, 57 (2018)..

Michel, J. B., Virmani, R., Arbustini, E.&Pasterkamp, G. Intraplaque haemorrhages as the trigger of plaque vulnerability.Eur. Heart J.32, 1977-1985 (2011)..

Jacques, S. L. Optical properties of biological tissues: a review.Phys. Med. Biol.58, R37 (2013)..

Chen, S. Y., Shu, X., Yi, J., Fawzi, A. A.&Zhang, H. F. Dual-band optical coherence tomography using a single supercontinuum laser source.J. Biomed. Opt.21, 066013 (2016)..

Liu, R. R. et al. Theoretical model for optical oximetry at the capillary level: exploring hemoglobin oxygen saturation through backscattering of single red blood cells.J. Biomed. Opt.22, 025002 (2017)..

Van Heel, M.&Schatz, M. Fourier shell correlation threshold criteria.J. Struct. Biol.151, 250-262 (2005)..

Winkelmann, J. A. et al. In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis.Opt. Lett.43, 619-622 (2018)..

Wojtkowski, M. et al. Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.Opt. Express12, 2404-2422 (2004)..

Jia, Y. L. et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography.Opt. Express20, 4710-4725 (2012)..

Araki, K. et al. Comparison of mucosal microvasculature between the proximal and distal human colon.J. Electron. Microsc.45, 202-206 (1996)..

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据