Single-cell biomagnifier for optical nanoscopes and nanotweezers

Yuchao Li; Xiaoshuai Liu; Baojun Li

doi:10.1038/s41377-019-0168-4

Go to Nature Website

Your Location：

Home >

Browse articles >

Single-cell biomagnifier for optical nanoscopes and nanotweezers

Article

- Single-cell biomagnifier for optical nanoscopes and nanotweezers
- Single-cell biomagnifier for optical nanoscopes and nanotweezers
- LSA 2019年8卷第6期页码：966-977
- Affiliations：
  
  Institute of Nanophotonics, Jinan University, 511443 Guangzhou, China
- Author bio：
  
  Baojun Li (baojunli@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-019-0168-4
  中图分类号：
- 纸质出版日期：2019，
  
  网络出版日期：2019-07-03，
  
  收稿日期：2019-01-27，
  
  修回日期：2019-05-30，
  
  录用日期：2019-06-02
- Accepted：
Scan QR Code
Single-cell biomagnifier for optical nanoscopes and nanotweezers[J]. LSA, 2019,8(6):966-977.

Li, Y. C., Liu, X. S. & Li, B. J. Single-cell biomagnifier for optical nanoscopes and nanotweezers. Light: Science & Applications, 8, 966-977 (2019).
Single-cell biomagnifier for optical nanoscopes and nanotweezers[J]. LSA, 2019,8(6):966-977. DOI： 10.1038/s41377-019-0168-4.

Li, Y. C., Liu, X. S. & Li, B. J. Single-cell biomagnifier for optical nanoscopes and nanotweezers. Light: Science & Applications, 8, 966-977 (2019). DOI： 10.1038/s41377-019-0168-4.

摘要

Abstract

Optical microscopes and optical tweezers

which were invented to image and manipulate microscale objects

have revolutionize

d cellular and molecular biology. However

the optical resolution is hampered by the diffraction limit; thus

optical microscopes and optical tweezers cannot be directly used to image and manipulate nano-objects. The emerging plasmonic/photonic nanoscopes and nanotweezers can achieve nanometer resolution

but the high-index material structures will easily cause mechanical and photothermal damage to biospecimens. Here

we demonstrate subdiffraction-limit imaging and manipulation of nano-objects by a noninvasive device that was constructed by trapping a cell on a fiber tip. The trapped cell

acting as a biomagnifier

could magnify nanostructures with a resolution of 100 nm (

/5.5) under white-light microscopy. The focus of the biomagnifier formed a nano-optical trap that allowed precise manipulation of an individual nanoparticle with a radius of 50 nm. This biomagnifier provides a high-precision tool for optical imaging

sensing

and assembly of bionanomaterials.

关键词

Keywords

references

Pahlevaninezhad, H. et al. Nano-optic endoscope for high-resolution optical coherence tomography in vivo.Nat. Photonics12, 540-547 (2018)..

Gu, M. et al. Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy.Light Sci. Appl.3, e126 (2014)..

Svoboda, K.&Block, S. M. Biological applications of optical forces.Annu. Rev. Biophys. Biomol. Struct.23, 247-285 (1994)..

Rodríguez-Sevilla, P. et al. Optical trapping for biosensing: materials and applications.J. Mater. Chem. B5, 9085-9101 (2017)..

Huang, B., Babcock, H.&Zhuang, X. W. Breaking the diffraction barrier: super-resolution imaging of cells.Cell143, 1047-1058 (2010)..

Kner, P. et al. Super-resolution video microscopy of live cells by structured illumination.Nat. Methods6, 339-342 (2009)..

Sahl, S. J. et al. Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids.Proc. Natl. Acad. Sci. USA.107, 6829-6834 (2010)..

Kusumi, A. et al. Tracking single molecules at work in living cells.Nat. Chem. Biol.10, 524-532 (2014)..

Pauzauskie, P. J. et al. Optical trapping and integration of semiconductor nanowire assemblies in water.Nat. Mater.5, 97-101 (2006)..

Lin, L. H. et al. Opto-thermoelectric nanotweezers.Nat. Photonics12, 195-201 (2018)..

Grier, D. G. A revolution in optical manipulation.Nature424, 810-816 (2003)..

Ashkin, A., Dziedzic, J. M.&Yamane, T. Optical trapping and manipulation of single cells using infrared laser beams.Nature330, 769-771 (1987)..

Dholakia, K., Reece, P.&Gu, M. Optical micromanipulation.Chem. Soc. Rev.37, 42-55 (2008)..

Maragò, O. M. et al. Optical trapping and manipulation of nanostructures.Nat. Nanotechnol.8, 807-819 (2013)..

Kawata, S., Inouye, Y.&Verma, P. Plasmonics for near-field nano-imaging and superlensing.Nat. Photonics3, 388-394 (2009)..

Hao, X. et al. From microscopy to nanoscopy via visible light.Light Sci. Appl.2, e108 (2013)..

Berthelot, J. et al. Three-dimensional manipulation with scanning near-field optical nanotweezers.Nat. Nanotechnol.9, 295-299 (2014)..

Alù, A.&Engheta, N. Cloaked near-field scanning optical microscope tip for noninvasive near-field imaging.Phys. Rev. Lett.105, 263906 (2010)..

Zhang, X.&Liu, Z. W. Superlenses to overcome the diffraction limit.Nat. Mater.7, 435-441 (2008)..

Juan, M. L., Righini, M.&Quidant, R. Plasmon nano-optical tweezers.Nat. Photonics5, 349-356 (2011)..

Chen, Y. F. et al. Controlled photonic manipulation of proteins and other nanomaterials.Nano Lett.12, 1633-1637 (2012)..

Yan, R. et al. Nanowire-based single-cell endoscopy.Nat. Nanotechnol.7, 191-196 (2012)..

Vo-Dinh, T. et al. Antibody-based nanoprobe for measurement of a fluorescent analyte in a single cell.Nat. Biotechnol.18, 764-767 (2000)..

Shambat, G. et al. Single-cell photonic nanocavity probes.Nano Lett.13, 4999-5005 (2013)..

Huang, X. H. et al. Plasmonic photothermal therapy (PPTT) using gold nanoparticles.Lasers Med. Sci.23, 217-228 (2008)..

Wang, K. et al. Trapping and rotating nanoparticles using a plasmonic nano-tweezer with an integrated heat sink.Nat. Commun.2, 469 (2011)..

Wang, Z. B. et al. Optical virtual imaging at 50 nm lateral resolution with a white-light nanoscope.Nat. Commun.2, 218 (2011)..

Yan, Y. Z. et al. Microsphere-coupled scanning laser confocal nanoscope for sub-diffraction-limited imaging at 25 nm lateral resolution in the visible spectrum.ACS Nano8, 1809-1816 (2014)..

Yang, H. et al. Super‐resolution biological microscopy using virtual imaging by a microsphere nanoscope.Small10, 1712-1718 (2014)..

Li, L. et al. Label-free super-resolution imaging of adenoviruses by submerged microsphere optical nanoscopy.Light Sci. Appl.2, e104 (2013)..

Yang, H. et al. Super-resolution imaging of a dielectric microsphere is governed by the waist of its photonic nanojet.Nano Lett.16, 4862-4870 (2016)..

Fan, W. et al. Three-dimensional all-dielectric metamaterial solid immersion lens for subwavelength imaging at visible frequencies.Sci. Adv.2, e1600901 (2016)..

Monks, J. N. et al. Spider silk: mother nature's bio-superlens.Nano Lett.16, 5842-5845 (2016)..

Wang, F. F. et al. Scanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging.Nat. Commun.7, 13748 (2016)..

Miccio, L. et al. Red blood cell as an adaptive optofluidic microlens.Nat. Commun.6, 6502 (2015)..

Li, Y. C. et al. Enhancing upconversion fluorescence with a natural bio-microlens.ACS Nano11, 10672-10680 (2017)..

Olof, S. N. et al. Measuring nanoscale forces with living probes.Nano Lett.12, 6018-6023 (2012)..

Li, Y. C. et al. Living nanospear for near-field optical probing.ACS Nano12, 10703-10711 (2018)..

Franze, K. et al. Müller cells are living optical fibers in the vertebrate retina.Proc. Natl. Acad. Sci. USA.104, 8287-8292 (2007)..

Xin, H. et al.Escherichia coli-based biophotonic waveguides.Nano Lett.13, 3408-3413 (2013)..

Lei, H. X. et al. Photophoretic assembly of two-dimensional crystals from microparticle suspensions.J. Opt.14, 035603 (2012)..

Demergis, V.&Florin, E. L. Ultrastrong optical binding of metallic nanoparticles.Nano Lett.12, 5756-5760 (2012)..

Neuman, K. C.&Block, S. M. Optical trapping.Rev. Sci. Instrum.75, 2787-2809 (2004)..

Yang, A. H. J. et al. Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguides.Nature457, 71-75 (2009)..

Grigorenko, A. N. et al. Nanometric optical tweezers based on nanostructured substrates.Nat. Photonics2, 365-370 (2008)..

Juan, M. L. et al. Self-induced back-action optical trapping of dielectric nanoparticles.Nat. Phys.5, 915-919 (2009)..

Chen, Z. G., Taflove, A.&Backman, V. Photonic nanojet enhancement of backscattering of light by nanoparticles: a potential novel visible-light ultramicroscopy technique.Opt. Express12, 1214-1220 (2004)..

Yang, H., Cornaglia, M.&Gijs, M. A. M. Photonic nanojet array for fast detection of single nanoparticles in a flow.Nano Lett.15, 1730-1735 (2015)..

Li, Y. C. et al. Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet.Light Sci. Appl.5, e16176 (2016)..

Schmidt, B. S. et al. Optofluidic trapping and transport on solid core waveguides within a microfluidic device.Opt. Express15, 14322-14334 (2007)..

Ashkin, A. et al. Observation of a single-beam gradient force optical trap for dielectric particles.Opt. Lett.11, 288-290 (1986)..

Allen, K. W. et al. Overcoming the diffraction limit of imaging nanoplasmonic arrays by microspheres and microfibers.Opt. Express23, 24484-24496 (2015)..

Allen, K. W. et al. Super-resolution microscopy by movable thin-films with embedded microspheres: resolution analysis.Ann. Phys.527, 513-522 (2015)..

Darafsheh, A. et al. Advantages of microsphere-assisted super-resolution imaging technique over solid immersion lens and confocal microscopies.Appl. Phys. Lett.104, 061117 (2014)..

Darafsheh, A. et al. Optical super-resolution by high-index liquid-immersed microspheres.Appl. Phys. Lett.101, 141128 (2012)..

Maslov, A. V.&Astratov, V. N. Imaging of sub-wavelength structures radiating coherently near microspheres.Appl. Phys. Lett.108, 051104 (2016)..

Maslov, A. V.&Astratov, V. N. Optical nanoscopy with contact Mie-particles: resolution analysis.Appl. Phys. Lett.110, 261107 (2017)..

Yang, X. S. et al. Mirror-enhanced super-resolution microscopy.Light Sci. Appl.5, e16134 (2016)..

Li, Y. C. et al. Optical separation and controllable delivery of cells from particle and cell mixture.Nanophotonics4, 353-360 (2015)..

Yakubovsky, D. I. et al. Optical constants and structural properties of thin gold films.Opt. Express25, 25574-25587 (2017)..

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据