Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Zhongjian Xie; Minhua Peng; Ruitao Lu; Xiangying Meng; Weiyuan Liang; Zhongjun Li; Meng Qiu; Bin Zhang; Guohui Nie; Ni Xie; Han Zhang; Paras N. Prasad

doi:10.1038/s41377-020-00388-3

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Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Original Articles

- Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy
- Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy
- LSA 2020年9卷第5期页码：1534-1548
- Affiliations：
  
  1.Shenzhen International Institute for Biomedical Research, Shenzhen 518116 Guangdong, PR China
  2.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055 Guangdong, PR China
  3.School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436 Guangdong, PR China
  4.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Institute of Microscale Optoelectronics, and Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, Shenzhen 518060, PR China
  5.Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China), Ministry of Education, Qingdao 266100, PR China
  6.Department of Chemistry, Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, StateUniversity of New York, Buffalo, NY, USA
- Author bio：
  
  Han Zhang (hzhang@szu.edu.cn)
  Paras N. Prasad (pnprasad@buffalo.edu)
- Funds：
- DOI：10.1038/s41377-020-00388-3
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-09-15，
  
  收稿日期：2020-04-15，
  
  修回日期：2020-07-13，
  
  录用日期：2020-08-13
- Accepted：
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Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy[J]. LSA, 2020,9(5):1534-1548.

Xie, Z. J. et al. Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy. Light: Science & Applications, 9, 1534-1548 (2020).
Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy[J]. LSA, 2020,9(5):1534-1548. DOI： 10.1038/s41377-020-00388-3.

Xie, Z. J. et al. Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy. Light: Science & Applications, 9, 1534-1548 (2020). DOI： 10.1038/s41377-020-00388-3.

摘要

Abstract

Here

we describe a combination strategy of black phosphorus (BP)-based photothermal therapy together with anti-CD47 antibody (aCD47)-based immunotherapy to synergistically enhance cancer treatment. Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance

along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment

remains a significant challenge for cancer immunotherapy. aCD47

an agent for CD47/SIRPα axis blockade

induces modest phagocytic activity and a low response rate for monotherapy

resulting in failures in clinical trials. We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation

improving the inherently poor immunogenicity of tumours

which is particularly useful for enhancing cancer immunotherapy. BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses

thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers. Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy.

关键词

Keywords

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