1.ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain
2.Ipsumio B.V., High Tech Campus, 5656 AE, Eindhoven, Netherlands
3.Department of Photonics Engineering, Technical University of Denmark, DK-2800 Kgs Lyngby, Denmark
4.Research Group Mechanical Process Engineering, Institute of Process Engineering and Environmental Technology, Technische Universität Dresden, Münchner Platz 3, D-01062 Dresden, Germany
5.School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, UK
6.IRIS Technology Solutions, SL, 08860 Castelldefels (Barcelona), Spain
7.ICREA-Institució Catalana de Recerca i Estudis Avan?ats, 08010 Barcelona, Spain
Valerio Pruneri (valerio.pruneri@icfo.eu)
纸质出版日期:2020,
网络出版日期:2020-02-12,
收稿日期:2019-06-06,
修回日期:2020-01-09,
录用日期:2020-01-27
Scan QR Code
An ultra-compact particle size analyser using a CMOS image sensor and machine learning[J]. LSA, 2020,9(1):176-186.
Hussain, R. et al. An ultra-compact particle size analyser using a CMOS image sensor and machine learning. Light: Science & Applications, 9, 176–186 (2020).
An ultra-compact particle size analyser using a CMOS image sensor and machine learning[J]. LSA, 2020,9(1):176-186. DOI: 10.1038/s41377-020-0255-6.
Hussain, R. et al. An ultra-compact particle size analyser using a CMOS image sensor and machine learning. Light: Science & Applications, 9, 176–186 (2020). DOI: 10.1038/s41377-020-0255-6.
Light scattering is a fundamental property that can be exploited to create essential devices such as particle analysers. The most common particle size analyser relies on measuring the angle-dependent diffracted light from a sample illuminated by a laser beam. Compared to other non-light-based counterparts
such a laser diffraction scheme offers precision
but it does so at the expense of size
complexity and cost. In this paper
we introduce the concept of a new particle size analyser in a collimated beam configuration using a consumer electronic camera and machine learning. The key novelty is a small form factor angular spatial filter that allows for the collection of light scattered by the particles up to predefined discrete angles. The filter is combined with a light-emitting diode and a complementary metal-oxide-semiconductor image sensor array to acquire angularly resolved scattering images. From these images
a machine learning model predicts the volume median diameter of the particles. To validate the proposed device
glass beads with diameters ranging from 13 to 125 µm were measured in suspension at several concentrations. We were able to correct for multiple scattering effects and predict the particle size with mean absolute percentage errors of 5.09% and 2.5% for the cases without and with concentration as an input parameter
respectively. When only spherical particles were analysed
the former error was significantly reduced (0.72%). Given that it is compact (on the order of ten cm) and built with low-cost consumer electronics
the newly designed particle size analyser has significant potential for use outside a standard laboratory
for example
in online and in-line industrial process monitoring.
Valsangkar, A. J. Principles, methods and applications of particle size analysis. Can. Geotech. J. 29, 1006 (1992).
Shekunov, B. Y. et al. Particle size analysis in pharmaceutics: principles, methods and applications. Pharm. Res. 24, 203-227 (2007).
Servais, C., Jones, R.&Roberts, I. The influence of particle size distribution on the processing of food. J. Food Eng. 51, 201-208 (2002).
Stetefeld, J., McKenna, S. A.&Patel, T. R. Dynamic light scattering: a practical guide and applications in biomedical sciences. Biophysical Rev. 8, 409-427 (2016).
Kim, A. et al. Validation of size estimation of nanoparticle tracking analysis on polydisperse macromolecule assembly. Sci. Rep. 9, 2639 (2019).
Kim, A., Bernt, W.&Cho, N. J. Improved size determination by nanoparticle tracking analysis: influence of recognition radius. Anal. Chem. 91, 9508-9515 (2019).
Blott, S. J. et al. Particle size analysis by laser diffraction. Geological Society, London, Special Publications. 232, 63-73 (2004).
Xu, R. L. Light scattering: a review of particle characterization applications. Particuology 18, 11-21 (2015).
Bux, J. et al. Measurement and density normalisation of acoustic attenuation and backscattering constants of arbitrary suspensions within the Rayleigh scattering regime. Appl. Acoust. 146, 9-22 (2019).
Povey, M. J. W. Ultrasound particle sizing: a review. Particuology 11, 135-147 (2013).
Vargas-Ubera, J., Aguilar, J. F.&Gale, D. M. Reconstruction of particle-size distributions from light-scattering patterns using three inversion methods. Appl. Opt. 46, 124-132 (2007).
Ye, Z.&Jiang, X. P. Wang, Z. C. Measurements of particle size distribution based on Mie scattering theory and Markov chain inversion algorithm. J. Softw. 7, 2309-2316 (2012).
Mishchenko, M. I., Travis, L. D.&Lacis, A. A.Multiple Scattering of Light by Particles: Radiative Transfer and Coherent Backscattering. (Cambridge University Press, Cambridge, 2006).
Gomi, H. Multiple scattering correction in the measurement of particle size and number density by the diffraction method. Appl. Opt. 25, 3552-3558 (1986).
Quirantes, A., Arroyo, F.&Quirantes-Ros, J. Multiple light scattering by spherical particle systems and its dependence on concentration: a T-matrix study. J. Colloid Interface Sci. 240, 78-82 (2001).
Wei, Y. H., Shen, J. Q.&Yu, H. T. Numerical calculation of multiple scattering with the layer model. Particuology 7, 76-82 (2009).
LeCun, Y., Bengio, Y.&Hinton, G. Deep learning. Nature 521, 436-444 (2015).
Nascimento, C. A. O., Guardani, R.&Giulietti, M. Use of neural networks in the analysis of particle size distributions by laser diffraction. Powder Technol. 90, 89-94 (1997).
Guardani, R., Nascimento, C. A. O.&Onimaru, R. S. Use of neural networks in the analysis of particle size distribution by laser diffraction: tests with different particle systems. Powder Technol. 126, 42-50 (2002).
Wu, Y. C. et al. Air quality monitoring using mobile microscopy and machine learning. Light Sci. Appl. 6, e17046, https://doi.org/10.1038/lsa.2017.46 (2017).
Roy, M. et al. Low-cost telemedicine device performing cell and particle size measurement based on lens-free shadow imaging technology. Biosens. Bioelectron. 67, 715-723 (2015).
Seo, S. et al. High-throughput lens-free blood analysis on a chip. Anal. Chem. 82, 4621-4627 (2010).
Cutler, A., Cutler, D. R.&Stevens, J. R. Random forests. InEnsemble Machine Learning(eds. Zhang, C.&Ma, Y. Q.) Ch. 5, 157-175 (Boston: Springer, 2012).https://doi.org/10.1007/978-1-4419-9326-7_5https://doi.org/10.1007/978-1-4419-9326-7_5..
Pruneri, V., Martïnez Cordero, P. A.&Jofre Cruanyes, M. Apparatus for measuring light scattering. US Patent 9857300 (2018).
Barton, G. et al. Fabrication of microstructured polymer optical fibres. Optical Fiber Technol. 10, 325-335 (2004).
Large, M. C. J. et al.Microstructured Polymer Optical Fibres. (Boston, Springer, 2008).
ISO 13320: 2009 Particle size analysis-laser diffraction methods (2009).
Retamal Marín, R. R. et al. Effects of sample preparation on particle size distributions of different types of silica in suspensions. Nanomaterials 8, 454 (2018).
Franklin, J. The elements of statistical learning: data mining, inference and prediction. Math. Intell. 27, 83-85 (2005).
Bohren, C. F.&Huffman, D. R.Absorption and Scattering of Light by Small Particles. (New York, John Wiley&Sons, 2008).
0
浏览量
0
Downloads
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621