Biophotonic sensors with integrated Si<sub>3</sub>N<sub>4</sub>-organic hybrid (SiNOH) lasers for point-of-care diagnostics

Daria Kohler; Gregor Schindler; Lothar Hahn; Johannes Milvich; Andreas Hofmann; Kerstin Länge; Wolfgang Freude; Christian Koos

doi:10.1038/s41377-021-00486-w

Go to Nature Website

Your Location：

Home >

Browse articles >

Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics

Articles

- Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics
- Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics
- LSA 2021年10卷第4期页码：648-659
- Affiliations：
  
  1.Institute of Photonics and Quantum Electronics (IPQ), Karlsruhe Institute of Technology (KIT), Engesserstrasse 5, 76131, Karlsruhe, Germany
  2.Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany
  3.Robert Bosch GmbH, Robert-Bosch-Campus 1, 71272, Renningen, Germany
  4.Institute for Automation and Applied Informatics (IAI), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany
- Author bio：
  
  Christian Koos (christian.koos@kit.edu)
- Funds：
- DOI：10.1038/s41377-021-00486-w
  中图分类号：
- 纸质出版日期：2021-04-30，
  
  网络出版日期：2021-03-26，
  
  收稿日期：2020-06-07，
  
  修回日期：2020-12-02，
  
  录用日期：2021-02-02
- Accepted：
Scan QR Code
Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics[J]. LSA, 2021,10(4):648-659.

Kohler, D. et al. Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics. Light: Science & Applications, 10, 648-659 (2021).
Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics[J]. LSA, 2021,10(4):648-659. DOI： 10.1038/s41377-021-00486-w.

Kohler, D. et al. Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics. Light: Science & Applications, 10, 648-659 (2021). DOI： 10.1038/s41377-021-00486-w.

摘要

Abstract

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection. Within this context

waveguide-(WG)-based optical biosensors on the silicon-nitride (Si

) platform represent a particularly promising option

offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range. However

while passive Si

-based photonic circuits lend themselves to highly scalable mass production

the integration of low-cost light sources remains a challenge. In this paper

we demonstrate optical biosensors that combine Si

sensor circuits with hybrid on-chip organic lasers. These Si

-organic hybrid (SiNOH) lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source. Fabrication of the devices is simple: The underlying Si

WGs are structured in a single lithography step

and the organic gain medium is subsequently applied by dispensing

spin-coating

or ink-jet printing processes. A highly parallel read-out of the optical sensor signals is accomplished with a simple camera. In our proof-of-concept experiment

we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length (

L-

)-related sensitivity of

S/L

= 0.16 rad nM

−1

. To our knowledge

this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source. We expect that the versatility of the device concept

the simple operation principle

and the compatibility with cost-efficient mass production will make the concept a highly

attractive option for applications in biophotonics and point-of-care diagnostics.

关键词

Keywords

references

Makarona, E. et al. Point-of-need bioanalytics based on planar optical interferometry.Biotechnol. Adv.34, 209–233 (2016)..

Luan, E. X. et al. Silicon photonic biosensors using label-free detection.Sensors18, 3519 (2018)..

Lim, H. W.&Soter, N. A.Clinical Photomedicine. (Marcel Dekker, 1993).

Palmer, K. F.&Williams, D. Optical properties of water in the near infrared.J. Opt. Soc. Am.64, 1107–1110 (1974)..

Muellner, P. et al. CMOS-compatible Si3N4waveguides for optical biosensing.Proc. Eng.120, 578–581 (2015)..

Subramanian, A. Z. et al. Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited].Photonics Res.3, B47–B59 (2015)..

Porcel, M. A. G. et al. [INVITED]Silicon nitride photonic integration for visible light applications.Optics Laser Technol.112, 299–306 (2019)..

Muñoz, P. et al. Silicon nitride photonic integration platforms for visible, near-infrared and mid-infrared applications.Sensors17, 2088 (2017)..

Blumenthal, D. J. et al. Silicon nitride in silicon photonics.Proc. IEEE106, 2209–2231 (2018)..

Huffman, T. A. et al. Integrated resonators in an ultralow loss Si3N4/SiO2platform for multifunction applications.IEEE J. Selected Topics Quantum Electron.24, 5900209 (2018)..

Sacher, W. D. et al. Monolithically integrated multilayer silicon nitride-on-silicon waveguide platforms for 3-D photonic circuits and devices.Proc. IEEE106, 2232–2245 (2018)..

Philipp, H. R. Optical properties of silicon nitride.J. Electrochem. Soc.120, 295–300 (1973)..

Malitson, I. H. Interspecimen comparison of the refractive index of fused silica.J. Opt. Soc. Am.55, 1205–1209 (1965)..

Schwarz, B. et al. Monolithically integrated mid-infrared lab-on-a-chip using plasmonics and quantum cascade structures.Nat. Commun.5, 4085 (2014)..

Wang, J. W., Yao, Z. S.&Poon, A. W. Integrated optofluidic label-free biosensors using a silicon-nitride-based coupled-resonator optical waveguide. inProc. SPIE 9750, Integrated Optics: Devices, Materials, and Technologies XX. (SPIE, 2016).

Taniguchi, T. et al. Detection of antibody-antigen reaction by silicon nitride slot-ring biosensors using protein G.Optics Commun.365, 16–23 (2016)..

Chatzianagnostou, E. et al. High-sensitivity plasmo-photonic interferometric sensors on a chip. in Proc. SPIE 11284, Smart Photonic and Optoelectronic Integrated Circuits XXII. (SPIE, 2020).

Geuzebroek, D. H. et al. Silicon-nitride biophotonic sensing platform. inProc. SPIE 10921, Integrated Optics: Devices, Materials, and Technologies XXIII. (SPIE, 2019).

Kohler, D. et al. Lasing in Si3N4-organic hybrid (SiNOH) spiral resonators. inProc. CLEO: Science and Innovations 2018. (Optical Society of America, 2018)..

Kohler, D. et al. Lasing in Si3N4-organic hybrid (SiNOH) waveguides.Optics Express28, 5085–5104 (2020)..

Vogelbacher, F. et al. Integrated silicon nitride organic hybrid DFB laser with inkjet printed gain medium.Optics Express27, 29350–29356 (2019)..

Vogelbacher, F. et al. Slot-waveguide silicon nitride organic hybrid distributed feedback laser.Sci. Rep.9, 18438 (2019)..

Vogelbacher, F. et al. A coupled-spiral silicon nitride organic-hybrid laser.IEEE Photonics Technol. Lett.32, 561–564 (2020)..

Kieninger, C. et al. Ultra-high electro-optic activity demonstrated in a silicon-organic hybrid modulator.Optica5, 739–748 (2018)..

Korn, D. et al. Lasing in silicon–organic hybrid waveguides.Nat. Commun.7, 10864 (2016)..

Bachmann, M., Besse, P. A.&Melchior, H. General self-imaging properties inN×Nmultimode interference couplers including phase relations.Appl. Optics33, 3905–3911 (1994)..

Halir, R. et al. Direct and sensitive phase readout for integrated waveguide sensors.IEEE Photonics J.5, 6800906 (2013)..

Reyes-Iglesias, R. J. et al. High-performance monolithically integrated 120° downconverter with relaxed hardware constraints.Optics Express20, 5725–5741 (2012)..

Shirshov, Y. M. et al. Analysis of the response of planar polarization interferometer to molecular layer formation: fibrinogen adsorption on silicon nitride surface.Biosens. Bioelectron.16, 381–390 (2001)..

Haake, H. M., Schütz, A.&Gauglitz, G. Label-free detection of biomolecular interaction by optical sensors.Fresenius' J. Anal. Chem.366, 576–585 (2000)..

Melnik, E. et al. Surface modification of integrated optical MZI sensor arrays using inkjet printing technology.Proc. Eng.168, 337–340 (2016)..

Wangüemert-Pérez, J. G. et al. [INVITED]Subwavelength structures for silicon photonics biosensing.Optics Laser Technol.109, 437–448 (2018)..

Milvich, J. et al. Surface sensing with integrated optical waveguides: a design guideline.Optics Express26, 19885–19906 (2018)..

Murib, M. S., Martens, D.&Bienstman, P. Label-free real-time optical monitoring of DNA hybridization using SiN Mach-Zehnder interferometer-based integrated biosensing platform.J. Biomed. Optics23, 127002 (2018)..

Prieto, F. et al. An integrated optical interferometric nanodevice based on silicon technology for biosensor applications.Nanotechnology14, 907–912 (2003)..

Thorlabs, Inc.Thorlabs GmbH.https://www.thorlabs.de/newgrouppage9.cfm?objectgroup_id=7https://www.thorlabs.de/newgrouppage9.cfm?objectgroup_id=7(2020)..

NaKu Technology Co., Ltd.NaKu Laser.https://www.civillaser.com/index.php?main_page=product_info&products_id=1038https://www.civillaser.com/index.php?main_page=product_info&products_id=1038(2020)..

Forget, S.&Chénais, S.Organic Solid-state Lasers. (Springer, 2013).

Chénais, S.&Forget, S. Recent advances in solid-state organic lasers.Polymer Int.61, 390–406 (2012)..

Ahmad, M. et al. Photostability of lasers based on pyrromethene 567 in liquid and solid-state host media.Optics Commun.203, 327–334 (2002)..

Estrada, I. A. et al. Multiplex detection of pathogen biomarkers in human blood, serum, and saliva using silicon photonic microring resonators. inProc. SPIE 9490, Advances in Global Health through Sensing Technologies 2015. (SPIE, 2015).

Martens, D. et al. A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine.Anal. Methods10, 3066–3073 (2018)..

Vemulapati, S.&Erickson, D. H.E.R.M.E. S: rapid blood-plasma separation at the point-of-need.Lab Chip18, 3285–3292 (2018)..

Hermes Life Science.https://www.hermeslifesciences.com/https://www.hermeslifesciences.com/(2020).

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据

Biophotonic sensors with integrated Si3N4-organic hybrid (SiNOH) lasers for point-of-care diagnostics

Biophotonic sensors with integrated Si3N4-organic hybrid (SiNOH) lasers for point-of-care diagnostics

DOI：10.1038/s41377-021-00486-w

摘要

Abstract

关键词

Keywords

references

Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics

Biophotonic sensors with integrated Si₃N₄-organic hybrid (SiNOH) lasers for point-of-care diagnostics