Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing

Nikita Toropov; Frank Vollmer

doi:10.1038/s41377-021-00517-6

Go to Nature Website

Your Location：

Home >

Browse articles >

Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing

News & Views

- Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing
- Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing
- LSA 2021年10卷第5期页码：710-712
- Affiliations：
  
  Department of Physics and Astronomy, Living Systems Institute, University of Exeter, Exeter, EX4 4QD, UK
- Author bio：
  
  Nikita Toropov (n.toropov@exeter.ac.uk)
  Frank Vollmer (f.vollmer@exeter.ac.uk)
- Funds：
- DOI：10.1038/s41377-021-00517-6
  中图分类号：
- 纸质出版日期：2021-05-31，
  
  网络出版日期：2021-04-14，
- Accepted：
Scan QR Code
Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing[J]. LSA, 2021,10(5):710-712.

Toropov, N. & Vollmer, F. Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing. Light: Science & Applications, 10, 710-712 (2021).
Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing[J]. LSA, 2021,10(5):710-712. DOI： 10.1038/s41377-021-00517-6.

Toropov, N. & Vollmer, F. Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing. Light: Science & Applications, 10, 710-712 (2021). DOI： 10.1038/s41377-021-00517-6.

摘要

Abstract

Researchers in the field of whispering-gallery-mode (WGM) microresonators have proposed biointegrated low-threshold WGM lasers

to enable large-scale parallel single-cell tracking and barcoding. Although the reported devices have so far been primarily investigated in model applications

most recent results represent important steps towards the development of in vivo tags and sensors that utilize the unique and narrow spectral features of miniature WGM lasers.

关键词

Keywords

references

Gather, M. C.&Yun, S. H. Single-cell biological lasers.Nat. Photonics5, 406-410 (2011)..

Humar, M.&Yun, S. H. Intracellular microlasers.Nat. Photonics9, 572-576 (2015)..

Schubert, M. et al. Lasing within live cells containing intracellular optical microresonators for barcode-type cell tagging and tracking.Nano Lett.15, 5647-5652(2015)..

Fikouras, A. H. et al. Non-obstructive intracellular nanolasers.Nat. Commun.9, 4817 (2018)..

Toropov, N. et al. Review of biosensing with whispering-gallery mode lasers.Light Sci. Appl.10, 42 (2021)..

Tang, S. J. et al. Laser particles with omnidirectional emission for cell tracking.Light Sci. Appl.10, 23 (2021)..

Vollmer, F.&Yu, D.Optical Whispering Gallery Modes for Biosensing(Springer, 2020).

Shao, L. B. et al. Detection of single nanoparticles and lentiviruses using microcavity resonance broadening.Adv. Mater.25, 5616-5620 (2013)..

Vollmer, F., Arnold, S.&Keng, D. Single virus detection from the reactive shift of a whispering-gallery mode.Proc. Natl. Acad. Sci. USA105, 20701-20704 (2008)..

Baaske, M. D.&Vollmer, F. Optical observation of single atomic ions interacting with plasmonic nanorods in aqueous solution.Nat. Photonics10, 733-739 (2016)..

Vincent, S., Subramanian, S.&Vollmer, F. Optoplasmonic characterisation of reversible disulfide interactions at single thiol sites in the attomolar regime.Nat. Commun.11, 2043 (2020)..

Kim, E. et al. Label-free optical detection of single enzyme-reactant reactions and associated conformational changes.Sci. Adv.3, e1603044 (2017)..

Möckl, L.&Moerner, W. E. Super-resolution microscopy with single molecules in biology and beyond-essentials, current trends, and future challenges.J. Am. Chem. Soc.142, 17828-17844 (2020)..

Dai, L. et al. Realization of a time-correlated photon counting technique for fluorescence analysis.Biomed. Opt. Express11, 2205-2212 (2020)..

Hellenkamp, B. et al. Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study.Nat. Methods15, 669-676 (2018)..

Halabi, E. A. et al. Dual-activatable cell tracker for controlled and prolonged single-cell labeling.ACS Chem. Biol.15, 1613-1620 (2020)..

Maetzig, T. et al. Lentiviral fluorescent genetic barcoding for multiplex fate tracking of leukemic cells.Mol. Ther. Methods Clin. Dev.6, 54-65 (2017)..

Cao, Z. X. et al. Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity.Light Sci Appl.8, 107 (2019)..

Liauw, B. W. H., Afsari, H. S.&Vafabakhsh, R. Conformational rearrangement during activation of a metabotropic glutamate receptor.Nat. Chem. Biol.17, 291-297 (2021)..

Schubert, M. et al. Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators.Sci. Rep.7, 40877 (2017)..

Schubert, M. et al. Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers.Nat. Photonics14, 452-458 (2020)..

Himmelhaus, M.&Francois, A. In-vitro sensing of biomechanical forces in live cells bya whispering gallery mode biosensor.Biosens. Bioelectron.25, 418-427 (2009)..

Chen, Y. C.&Fan, X. D. Biological lasers for biomedical applications.Adv. Opt. Mater.7, 1900377 (2019)..

Keller, P. J. Imaging morphogenesis: technological advances and biological insights.Science340, 1234168 (2013)..

Martino, N. et al. Wavelength-encoded laser particles for massively multiplexed cell tagging.Nat. Photonics13, 720-727 (2019)..

Kwok, S. J. J. et al. Multiplexed laser particles for spatially resolved single-cell analysis.Light Sci. Appl.8, 74 (2019)..

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据