Shot-noise limited, supercontinuum-based optical coherence tomography

Shreesha Rao D.S.; Mikkel Jensen; Lars Grüner-Nielsen; Jesper Toft Olsen; Peter Heiduschka; Björn Kemper; Jürgen Schnekenburger; Martin Glud; Mette Mogensen; Niels Møller Israelsen; Ole Bang

doi:10.1038/s41377-021-00574-x

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Shot-noise limited, supercontinuum-based optical coherence tomography

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- Shot-noise limited, supercontinuum-based optical coherence tomography
- Shot-noise limited, supercontinuum-based optical coherence tomography
- LSA 2021年10卷第7期页码：1372-1384
- Affiliations：
  
  1.DTU Fotonik, Dept. of Photonics Engineering, Technical University of Denmark, Ørsteds Plads, 2800, Kongens Lyngby, Denmark
  2.NKT Photonics A/S, Blokken 84, 3460, Birkerød, Denmark
  3.Department of Ophthalmology, University of Münster Medical Centre, Domagkstr. 15, D-48149, Münster, Germany
  4.Biomedical Technology Center of the Medical Faculty, University of Münster, Mendelstr. 17, D-48149, Münster, Germany
  5.Department of Dermatology, Bisbebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark
- Author bio：
  
  Ole Bang (oban@fotonik.dtu.dk)
- Funds：
- DOI：10.1038/s41377-021-00574-x
  中图分类号：
- 纸质出版日期：2021-07-31，
  
  网络出版日期：2021-06-28，
  
  收稿日期：2020-10-22，
  
  修回日期：2021-05-26，
  
  录用日期：2021-06-07
- Accepted：
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Shot-noise limited, supercontinuum-based optical coherence tomography[J]. LSA, 2021,10(7):1372-1384.

Shreesha Rao, D. S. et al. Shot-noise limited, supercontinuum-based optical coherence tomography. Light: Science & Applications, 10, 1372-1384 (2021).
Shot-noise limited, supercontinuum-based optical coherence tomography[J]. LSA, 2021,10(7):1372-1384. DOI： 10.1038/s41377-021-00574-x.

Shreesha Rao, D. S. et al. Shot-noise limited, supercontinuum-based optical coherence tomography. Light: Science & Applications, 10, 1372-1384 (2021). DOI： 10.1038/s41377-021-00574-x.

摘要

Abstract

We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage

we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber

pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast

better sensitivity

and improved penetration. From SD-OCT imaging of skin

retina

and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection.

关键词

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references

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