Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

Lanhua Liu; Xuejun Zhang; Qian Zhu; Kaiwei Li; Yun Lu; Xiaohong Zhou; Tuan Guo

doi:10.1038/s41377-021-00618-2

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Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs

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- Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs
- Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs
- LSA 2021年第10期页码：1849-1861
- Affiliations：
  
  1.State Key Joint Laboratory of ESPC, School of Environment, Tsinghua University, Beijing, 100084, China
  2.Institute of Photonics Technology, Jinan University, Guangzhou, 510632, China
- Author bio：
  
  Xiaohong Zhou (xhzhou@mail.tsinghua.edu.cn)
  Tuan Guo (tuanguo@jnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00618-2
  中图分类号：
- 纸质出版日期：2021-10-31，
  
  网络出版日期：2021-09-07，
  
  收稿日期：2021-05-29，
  
  修回日期：2021-08-14，
  
  录用日期：2021-08-17
- Accepted：
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Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs[J]. LSA, 2021,(10):1849-1861.

Liu, L. H. et al. Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs. Light: Science & Applications, 10, 1849-1861 (2021).
Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs[J]. LSA, 2021,(10):1849-1861. DOI： 10.1038/s41377-021-00618-2.

Liu, L. H. et al. Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs. Light: Science & Applications, 10, 1849-1861 (2021). DOI： 10.1038/s41377-021-00618-2.

摘要

Abstract

The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of detecting endocrine disruptors. However

a long-lasting challenge unaddressed is how to achieve ultrahigh sensitive

continuous

and in situ measurement with a portable device for in-field and remote environmental monitoring. Here we demonstrate a simple-to-implement plasmonic optical fiber biosensing platform to achieve an improved light–matter interaction and advanced surface chemistry for ultrasensitive detection of endocrine disruptors. Our platform is based on a gold-coated highly tilted fiber Bragg grating that excites high-density narrow cladding mode spectral combs that overlap with the broad absorption of the surface plasmon for high accurac

y interrogation

hence enabling the ultrasensitive monitoring of refractive index changes at the fiber surface. Through the use of estrogen receptors as the model

we design an estradiol–streptavidin conjugate with the assistance of molecular dynamics

converting the specific recognition of environmental estrogens (EEs) by estrogen receptor into surface-based affinity bioassay for protein. The ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5 × 10

−3

ng ml

−1

estradiol equivalent concentration level

which is one order lower than the defined maximal E

level in drinking water set by the Japanese government. The capability to detect EEs down to nanogram per liter level is the lowest limit of detection for any estrogen receptor-based detection reported thus far. Its compact size

flexible shape

and remote operation capability open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-to-reach spaces

thereby having the potential to revolutionize environment and health monitoring.

关键词

Keywords

references

Hunt, J. P. et al. Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions.Analyst142, 4595–4600 (2017)..

Ismail, N. A. H. et al. Quantification of multi-classes of endocrine-disrupting compounds in estuarine water.Environ. Pollut.249, 1019–1028 (2019)..

Yao, B. et al. Occurrence and estrogenic activity of steroid hormones in Chinese streams: a nationwide study based on a combination of chemical and biological tools.Environ. Int.118, 1–8 (2018)..

Memon, A. G. et al. Ultrasensitive colorimetric aptasensor for Hg2+detection using Exo-III assisted target recycling amplification and unmodified AuNPs as indicators.J. Hazard. Mater.384, 120948 (2020)..

Brzozowski, A. M. et al. Molecular basis of agonism and antagonism in the oestrogen receptor.Nature389, 753–758 (1997)..

Rodriguez-Mozaz, S. et al. Biosensors for environmental monitoring of endocrine disruptors: a review article.Anal. Bioanal. Chem.378, 588–598 (2004)..

Björnström, L.&Sjöberg, M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes.Mol. Endocrinol.19, 833–842 (2005)..

Carvalho, R. N. et al. Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?Toxicol. Sci.141, 218–233 (2014)..

Seifert, M., Haindl, S.&Hock, B. Development of an enzyme linked receptor assay (ELRA) for estrogens and xenoestrogens.Anal. Chim. Acta386, 191–199 (1999)..

Garrett, S. D., Lee, H. A.&Morgan, M. R. A. A nonisotopic estrogen receptor–based assay to detect estrogenic compounds.Nat. Biotechnol.17, 1219–1222 (1999)..

Shelby, M. D. et al. Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays.Environ. Health Perspect.104, 1296–1300 (1996)..

Kuiper, G. G. J. M. et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β.Endocrinology138, 863–870 (1997)..

Liu, L. H. et al. Facile screening of potential xenoestrogens by an estrogen receptor-based reusable optical biosensor.Biosens. Bioelectron.97, 16–20 (2017)..

Liu, L. H. et al. Triple functional small-molecule-protein conjugate mediated optical biosensor for quantification of estrogenic activities in water samples.Environ. Int.132, 105091 (2019)..

La Spina, R. et al. Label-free biosensor detection of endocrine disrupting compounds using engineered estrogen receptors.Biosensors8, 1 (2018)..

Fechner, P. et al. An advanced biosensor for the prediction of estrogenic effects of endocrine-disrupting chemicals on the estrogen receptor alpha.Anal. Bioanal. Chem.393, 1579–1585 (2009)..

Gao, Y., Li, X. X.&Guo, L. H. Assessment of estrogenic activity of perfluoroalkyl acids based on ligand-induced conformation state of human estrogen receptor.Environ. Sci. Technol.47, 634–641 (2013)..

Mo, Z. H., Long, X. H.&Fu, W. L. A new sandwich-type assay of estrogen using piezoelectric biosensor immobilized with estrogen response element.Anal. Commun.36, 281–283 (1999)..

Murata, M. et al. Novel biosensor for the rapid measurement of estrogen based on a ligand-receptor interaction.Anal. Sci.17, 387–390 (2001)..

Xia, W. et al. Electrochemical biosensor for estrogenic substance using lipid bilayers modified by Au nanoparticles.Biosens. Bioelectron.25, 2253–2258 (2010)..

Asano, H., Maeda, T.&Shiraishi, Y. Sensitive determination of hexavalent chromium using a microfluidic paper-based analytical device with solid phase extraction.Bunseki Kagaku70, 379–383 (2021)..

Caucheteur, C., Guo, T.&Albert, J. Review of plasmonic fiber optic biochemical sensors: improving the limit of detection.Anal. Bioanal. Chem.407, 3883–3897 (2015)..

Allsop, T. D. P. et al. An ultra-sensitive aptasensor on optical fibre for the direct detection of bisphenol A.Biosens. Bioelectron.135, 102–110 (2019)..

Lamarca, R. S. et al. Label-free ultrasensitive and environment-friendly immunosensor based on a silica optical fiber for the determination of ciprofloxacin in wastewater samples.Anal. Chem.92, 14415–14422 (2020)..

Pollet, J. et al. Fiber optic SPR biosensing of DNA hybridization and DNA–protein interactions.Biosens. Bioelectron.25, 864–869 (2009)..

Albert, J. et al. Tilted fiber Bragg grating sensors.Laser Photonics Rev.7, 83–108 (2013)..

Guo, T. Fiber grating-assisted surface Plasmon resonance for biochemical and electrochemical sensing.J. Lightwave Technol.35, 3323–3333 (2017)..

Caucheteur, C. et al. Ultrasensitive plasmonic sensing in air using optical fibre spectral combs.Nat. Commun.7, 13371 (2016)..

Cai, S. S. et al. Narrow bandwidth fiber-optic spectral combs for renewable hydrogen detection.Sci. China Inf. Sci.63, 222401 (2020)..

Chen, Y. Y. et al. Optical biosensors based on refractometric sensing schemes: a review.Biosens. Bioelectron.144, 111693 (2019)..

Zhu, Q. et al. In silico study of molecular mechanisms of action: estrogenic disruptors among phthalate esters.Environ. Pollut.255, 113193 (2019)..

Erdogan, T.&Sipe, J. E. Tilted fiber phase gratings.J. Optical Soc. Am. A13, 296–313 (1996)..

Fu, L. et al. Discrimination of bulk and surface refractive index change in plasmonic sensors with narrow bandwidth resonance combs.ACS Sens.6, 3013–3023 (2021).https://doi.org/10.1021/acssensors.1c00906https://doi.org/10.1021/acssensors.1c00906..

Chiavaioli, F. et al. Femtomolar detection by nanocoated fiber label-free biosensors.ACS Sens.3, 936–943 (2018)..

Chiavaioli, F. et al. Towards a uniform metrological assessment of grating-based optical fiber sensors: from refractometers to biosensors.Biosensors7, 23 (2017)..

Takeuchi, S. et al. Differential effects of phthalate esters on transcriptional activities via human estrogen receptors α and β, and androgen receptor.Toxicology210, 223–233 (2005)..

Zhou, X. H. et al. A reusable evanescent wave immunosensor for highly sensitive detection of bisphenol A in water samples.Sci. Rep.4, 4572 (2014)..

Guo, T. et al. Plasmonic optical fiber-grating immunosensing: a review.Sensors17, 2732 (2017)..

Yuan, Y. et al. Electrochemical surface Plasmon resonance fiber-optic sensor: in situ detection of electroactive biofilms.Anal. Chem.88, 7609–7616 (2016)..

Lao, J. J. et al. In situ plasmonic optical fiber detection of the state of charge of supercapacitors for renewable energy storage.Light. Sci. Appl.7, 34 (2018)..

Si, Y. et al. Electrochemical plasmonic fiber-optic sensors for ultra-sensitive heavy metal detection.J. Lightwave Technol.37, 3495–3502 (2019)..

Zhang, X. J. et al. In situ determination of the complex permittivity of ultrathin H2-infused palladium coatings for plasmonic fiber optic sensors in the near infrared.J. Mater. Chem. C6, 5161–5170 (2018)..

Shi, Y. Z. et al. Chirality-assisted lateral momentum transfer for bidirectional enantioselective separation.Light. Sci. Appl.9, 62 (2020)..

Toropov, N. et al. Review of biosensing with whispering-gallery mode lasers.Light. Sci. Appl.10, 42 (2021)..

Pan, T. et al. Biophotonic probes for bio-detection and imaging.Light. Sci. Appl.10, 124 (2021)..

Fang, H. et al. Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.Chem. Res. Toxicol.14, 280–294 (2001)..

Wang, R. Y. et al. T–T mismatch-driven biosensor using triple functional DNA-protein conjugates for facile detection of Hg2+.Biosens. Bioelectron.78, 418–422 (2016)..

Wang, D. et al. A recombinant estrogen receptor fragment-based homogeneous fluorescent assay for rapid detection of estrogens.Biosens. Bioelectron.55, 391–395 (2014)..

Hock, B., Seifert, M.&Kramer, K. Engineering receptors and antibodies for biosensors.Biosens. Bioelectron.17, 239–249 (2002)..

Habauzit, D. et al. Determination of estrogen presence in water by SPR using estrogen receptor dimerization.Anal. Bioanal. Chem.390, 873–883 (2008)..

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