Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging

Jing Zhou; Xiaoxiao Fan; Di Wu; Jie Liu; Yuhuang Zhang; Zikang Ye; Dingwei Xue; Mubin He; Liang Zhu; Zhe Feng; Andrey N. Kuzmin; Wen Liu; Paras N. Prasad; Jun Qian

doi:10.1038/s41377-021-00627-1

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Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging

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- Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging
- Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging
- LSA 2021年10卷第10期页码：1877-1888
- Affiliations：
  
  1.State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, 310058, China
  2.Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China
  3.Key Laboratory of Flexible Electronics (KLOFE) Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech), Nanjing, 211800, China
  4.Department of Chemistry, Zhejiang University, Hangzhou, 310058, China
  5.Interdisciplinary Institute of Neuroscience and Technology (ZIINT), College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China
  6.Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA
  7.Key Laboratory of Optical Information Detection and Display Technology of Zhejiang, Zhejiang Normal University, Jinhua, 321004, China
- Author bio：
  
  Paras N. Prasad (pnprasad@buffalo.edu)
  Jun Qian (qianjun@zju.edu.cn)
- Funds：
- DOI：10.1038/s41377-021-00627-1
  中图分类号：
- 纸质出版日期：2021-10-31，
  
  网络出版日期：2021-09-13，
  
  收稿日期：2021-05-07，
  
  修回日期：2021-08-21，
  
  录用日期：2021-08-30
- Accepted：
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Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging[J]. LSA, 2021,10(10):1877-1888.

Zhou, J. et al. Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging. Light: Science & Applications, 10, 1877-1888 (2021).
Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging[J]. LSA, 2021,10(10):1877-1888. DOI： 10.1038/s41377-021-00627-1.

Zhou, J. et al. Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging. Light: Science & Applications, 10, 1877-1888 (2021). DOI： 10.1038/s41377-021-00627-1.

摘要

Abstract

Bright anti-Stokes fluorescence (ASF) in the first near-infrared spectral region (NIR-I

800 nm–900 nm) under the excitation of a 915 nm continuous wave (CW) laser

is observed in Indocyanine Green (ICG)

a dye approved by the Food and Drug Administration for clinical use. The dependence of fluorescence intensity on excitation light power and temperature

together with fluorescence lifetime measurement

establish this ASF to be originated from absorption from a thermally excited vibrational level (hot-band absorption)

as shown in our experiments

which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped nanoparticles. To test the utility of this ASF NIR-I probe for advanced bioimaging

we successively apply it for biothermal sensing

cerebral blood vessel tomography and blood stream velocimetry. Moreover

in combination with L1057 nanoparticles

which absorb the ASF of ICG and emit beyond 1100 nm

these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW laser. One channel is used to monitor two overlapping organs

urinary system & blood vessel of a live mouse

while the other shows urinary system only. Using in intraoperative real-time monitoring

such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery.

关键词

Keywords

references

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