Non-invasive photoacoustic computed tomography of rat heart anatomy and function

Li Lin; Xin Tong; Susana Cavallero; Yide Zhang; Shuai Na; Rui Cao; Tzung K. Hsiai; Lihong V. Wang

doi:10.1038/s41377-022-01053-7

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Non-invasive photoacoustic computed tomography of rat heart anatomy and function

Original Articles

- Non-invasive photoacoustic computed tomography of rat heart anatomy and function
- Non-invasive photoacoustic computed tomography of rat heart anatomy and function
- 光：科学与应用 2023年12卷第1期页码：109-117
- Affiliations：
  
  1.Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, USA
  2.Department of Bioengineering, UCLA, Los Angeles, CA, USA
  3.Division of Cardiology, Department of Medicine, UCLA, Los Angeles, CA, USA
  4.Present address: College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
  5.Present address: The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Author bio：
  
  Tzung K. Hsiai (THsiai@mednet.ucla.edu)
  Lihong V. Wang (LVW@caltech.edu)
- Funds：
- DOI：10.1038/s41377-022-01053-7
  中图分类号：
- 纸质出版日期：2023-1-31，
  
  网络出版日期：2023-1-3，
  
  收稿日期：2022-7-11，
  
  修回日期：2022-11-29，
  
  录用日期：2022-12-1
Scan for full text
Non-invasive photoacoustic computed tomography of rat heart anatomy and function[J]. 光：科学与应用, 2023,12(1):109-117.

Lin, L. et al. Non-invasive photoacoustic computed tomography of rat heart anatomy and function. Light: Science & Applications, 12, 109-117 (2023).
Non-invasive photoacoustic computed tomography of rat heart anatomy and function[J]. 光：科学与应用, 2023,12(1):109-117. DOI： 10.1038/s41377-022-01053-7.

Lin, L. et al. Non-invasive photoacoustic computed tomography of rat heart anatomy and function. Light: Science & Applications, 12, 109-117 (2023). DOI： 10.1038/s41377-022-01053-7.

摘要

Abstract

Complementary to mainstream cardiac imaging modalities for preclinical research

photoacoustic computed tomography (PACT) can provide functional optical contrast with high imaging speed and resolution. However

PACT has not been demonstrated to reveal the dynamics of whole cardiac anatomy or vascular system without surgical procedure (thoracotomy) for tissue penetration. Here

we achieved non-invasive imaging of rat hearts using the recently developed three-dimensional PACT (3D-PACT) platform

demonstrating the regulated illumination and detection schemes to reduce the effects of optical attenuation and acoustic distortion through the chest wall; thereby

enabling unimpeded visualization of the cardiac anatomy and intracardiac hemodynamics following rapidly scanning the heart within 10 s. We further applied 3D-PACT to reveal distinct cardiac structural and functional changes among the healthy

hypertensive

and obese rats

with optical contrast to uncover differences in cardiac chamber size

wall thickness

and hemodynamics. Accordingly

3D-PACT provides high imaging speed and nonionizing penetration to capture the whole heart for diagnosing the animal models

holding promises for clinical translation to cardiac imaging of human neonates.

关键词

Keywords

references

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