Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles

Rui Pu; Qiuqiang Zhan

doi:10.1038/s41377-023-01106-5

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Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles

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- Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles
- Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles
- 光：科学与应用 2023年12卷第4期页码：502-504
- Affiliations：
  
  Centre for Optical and Electromagnetic Research, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
- Author bio：
  
  Qiuqiang Zhan (zhanqiuqiang@m.scnu.edu.cn)
- Funds：
- DOI：10.1038/s41377-023-01106-5
  中图分类号：
- 纸质出版日期：2023-4-30，
  
  网络出版日期：2023-3-3，
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Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles[J]. 光：科学与应用, 2023,12(4):502-504.

Pu, R. & Zhan, Q. Q. Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles.Light: Science & Applications,12, 502-504 (2023).
Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles[J]. 光：科学与应用, 2023,12(4):502-504. DOI： 10.1038/s41377-023-01106-5.

Pu, R. & Zhan, Q. Q. Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles.Light: Science & Applications,12, 502-504 (2023). DOI： 10.1038/s41377-023-01106-5.

摘要

Abstract

Super-resolution microscopic imaging employing upconversion nanoparticles is applied to reveal the surface heterogeneity of tumor cell-derived small extracellular vesicles

i.e.

exosome. The number of surface antigens of every extracellular vesicles can be quantified by both the high imaging resolution and stable brightness of upconversion nanoparticles. This method proves its great potential in nanoscale biological studies.

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references

El Andaloussi, S. et al. Extracellular vesicles: biology and emerging therapeutic opportunities.Nat. Rev. Drug Discov.12, 347–357 (2013).

Huang, G. et al. Upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles.eLight2, 20 (2022).

Huang, G. et al. Single small extracellular vesicle (sEV) quantification by upconversion nanoparticles.Nano Lett.22, 3761–3769 (2022).

Chen, C. H. et al. Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles.Nat. Commun.9, 3290 (2018).

Liang, Y. S. et al. Migrating photon avalanche in different emitters at the nanoscale enables 46th-order optical nonlinearity.Nat. Nanotechnol.17, 524–530 (2022).

Wu, Q. S. et al. Non-bleaching fluorescence emission difference microscopy using single 808-nm laser excited red upconversion emission.Opt. Express25, 30885–30894 (2017).

Liu, Y. J. et al. Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy.Nature543, 229–233 (2017).

Zhan, Q. Q. et al. Achieving high-efficiency emission depletion nanoscopy by employing cross relaxation in upconversion nanoparticles.Nat. Commun.8, 1058 (2017).

Pu, R. et al. Super-resolution microscopy enabled by high-efficiency surface-migration emission depletion.Nat. Commun.13, 6636 (2022).

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