Chemiluminescent carbon nanodots for dynamic and guided antibacteria

Jiang-Fan Han; Qing Lou; Zhong-Zheng Ding; Guang-Song Zheng; Qing-Chao Ni; Run-Wei Song; Kai-Kai Liu; Jin-Hao Zang; Lin Dong; Cheng-Long Shen; Chong-Xin Shan

doi:10.1038/s41377-023-01149-8

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Chemiluminescent carbon nanodots for dynamic and guided antibacteria

Original Articles

- Chemiluminescent carbon nanodots for dynamic and guided antibacteria
- Chemiluminescent carbon nanodots for dynamic and guided antibacteria
- 光：科学与应用 2023年12卷第5期页码：915-927
- Affiliations：
  
  Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China
- Author bio：
  
  Qing Lou (louqing1986@zzu.edu.cn)
  Cheng-Long Shen (phyclshen@zzu.edu.cn)
  Chong-Xin Shan (cxshan@zzu.edu.cn)
- Funds：
- DOI：10.1038/s41377-023-01149-8
  中图分类号：
- 纸质出版日期：2023-5-31，
  
  网络出版日期：2023-5-4，
  
  收稿日期：2022-12-20，
  
  修回日期：2023-4-2，
  
  录用日期：2023-4-2
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Chemiluminescent carbon nanodots for dynamic and guided antibacteria[J]. 光：科学与应用, 2023,12(5):915-927.

Han, J. F. et al. Chemiluminescent carbon nanodots for dynamic and guided antibacteria. Light: Science & Applications, 12, 915-927 (2023).
Chemiluminescent carbon nanodots for dynamic and guided antibacteria[J]. 光：科学与应用, 2023,12(5):915-927. DOI： 10.1038/s41377-023-01149-8.

Han, J. F. et al. Chemiluminescent carbon nanodots for dynamic and guided antibacteria. Light: Science & Applications, 12, 915-927 (2023). DOI： 10.1038/s41377-023-01149-8.

摘要

Abstract

Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria. Image-guided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections. Herein

a chemiluminescence (CL)-dynamic/guided antibacteria (CDGA) with multiple reactive oxygen species (ROS) generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots (CDs) and peroxalate as CL fuels. Mechanistically

hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate

enabling bacterial induced inflammation imaging. Meanwhile

type Ⅰ/Ⅱ photochemical ROS production and type Ⅲ ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently. The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model. The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria

and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance

whose sterilizing rate is up to 99.99%.

关键词

Keywords

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