Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology

Marcello Meneghetti; Jaspreet Kaur; Kunyang Sui; Jakob F. Sørensen; Rune W. Berg; Christos Markos

doi:10.1038/s41377-023-01164-9

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Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology

Original Articles

- Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology
- Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology
- 光：科学与应用 2023年12卷第6期页码：1103-1116
- Affiliations：
  
  1.DTU Electro, Department of Electrical and Photonics Engineering, Technical University of Denmark, DK-2800 Kgs, Lyngby, Denmark
  2.Department of Neuroscience, University of Copenhagen, Blegdamsvej 3B, DK-2200 Kbh N, Copenhagen, Denmark
  3.NORBLIS ApS, Virumgade 35D, DK-2830 Virum, Denmark
- Author bio：
  
  Marcello Meneghetti (mamen@dtu.dk)
  Christos Markos (chmar@dtu.dk)
- Funds：
- DOI：10.1038/s41377-023-01164-9
  中图分类号：
- 纸质出版日期：2023-6-30，
  
  网络出版日期：2023-5-24，
  
  收稿日期：2022-12-6，
  
  修回日期：2023-4-14，
  
  录用日期：2023-4-17
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Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology[J]. 光：科学与应用, 2023,12(6):1103-1116.

Meneghetti, M. et al. Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology. Light: Science & Applications, 12, 1103-1116 (2023).
Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology[J]. 光：科学与应用, 2023,12(6):1103-1116. DOI： 10.1038/s41377-023-01164-9.

Meneghetti, M. et al. Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology. Light: Science & Applications, 12, 1103-1116 (2023). DOI： 10.1038/s41377-023-01164-9.

摘要

Abstract

Controlling neuronal activity using implantable neural interfaces constitutes an important tool to understand and develop novel strategies against brain diseases. Infrared neurostimulation is a promising alternative to optogenetics for controlling the neuronal circuitry with high spatial resolution. However

bi-directional interfaces capable of simultaneously delivering infrared light and recording electrical signals from the brain with minimal inflammation have not yet been reported. Here

we have developed a soft fibre-based device using high-performance polymers which are > 100-fold softer than conventional silica glass used in standard optical fibres. The developed implant is capable of stimulating the brain activity in localized cortical domains by delivering laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo from the motor cortex and hippocampus in acute and chronic settings

respectively. Immunohistochemical analysis of the brain tissue indicated insignificant inflammatory response to the infrared pulses while the signal-to-noise ratio of recordings still remained high. Our neural interface constitutes a step forward in expanding infrared neurostimulation as a versatile approach for fundamental research and clinically translatable therapies.

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references

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