Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism

Cheng Xu; Zhihao Ren; Hong Zhou; Jingkai Zhou; Chong Pei Ho; Nan Wang; Chengkuo Lee

doi:10.1038/s41377-023-01186-3

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Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism

Original Articles

- Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism
- Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism
- LSA 2023年12卷第7期页码：1401-1414
- Affiliations：
  
  1.Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore
  2.Center for Intelligent Sensors and MEMS (CISM), National University of Singapore, Singapore 117608, Singapore
  3.Institute of Microelectronics (IME), Agency for Science, Technology and Research (A*STAR), Singapore 138634, Singapore
  4.NUS Graduate School for Integrative Science and Engineering Program (ISEP), National University of Singapore, Singapore 117456, Singapore
- Author bio：
  
  Chengkuo Lee (elelc@nus.edu.sg)
- Funds：
- DOI：10.1038/s41377-023-01186-3
  中图分类号：
- 纸质出版日期：2023-07-31，
  
  网络出版日期：2023-06-25，
  
  收稿日期：2022-12-17，
  
  修回日期：2023-04-27，
  
  录用日期：2023-05-16
- Accepted：
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Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism[J]. LSA, 2023,12(7):1401-1414.

Xu, C. et al. Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism. Light: Science & Applications, 12, 1401-1414 (2023).
Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism[J]. LSA, 2023,12(7):1401-1414. DOI： 10.1038/s41377-023-01186-3.

Xu, C. et al. Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism. Light: Science & Applications, 12, 1401-1414 (2023). DOI： 10.1038/s41377-023-01186-3.

摘要

Abstract

Circular dichroism (CD) spectroscopy has been widely demonstrated for detecting chiral molecules. However

the determination of chiral mixtures with various concentrations and enantiomeric ratios can be a challenging task. To solve this problem

we report an enhanced vibrational circular dichroism (VCD) sensing platform based on plasmonic chiral metamaterials

which presents a 6-magnitude signal enhancement with a selectivity of chiral molecules. Guided by coupled-mode theory

we leverage both in-plane and out-of-plane symmetry-breaking structures for chiral metamaterial design enabled by a two-step lithography process

which increases the near-field coupling strengths and varies the ratio between absorption and radiation loss

resulting in improved chiral light-matter interaction and enhanced molecular VCD signals. Besides

we demonstrate the thin-film sensing process of BSA and β-lactoglobulin proteins

which contain secondary structures α-helix and β-sheet and achieve a limit of detection down to zeptomole level. Furthermore

we also

for the first time

explore the potential of enhanced VCD spectroscopy by demonstrating a selective sensing process of chiral mixtures

where the mixing ratio can be successfully differentiated with our proposed chiral metamaterials. Our findings improve the sensing signal of molecules and expand the extractable information

paving the way toward label-free

compact

small-volume chiral molecule detection for stereochemical and clinical diagnosis applications.

关键词

Keywords

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