Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

Hailong He; Nikolina-Alexia Fasoula; Angelos Karlas; Murad Omar; Juan Aguirre; Jessica Lutz; Michael Kallmayer; Martin Füchtenbusch; Hans-Henning Eckstein; Annette Ziegler; Vasilis Ntziachristos

doi:10.1038/s41377-023-01275-3

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Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

Original Articles

- Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy
- Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy
- LSA 2023年12卷第11期页码：2335-2349
- Affiliations：
  
  1.Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany
  2.Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany
  3.Department for Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany
  4.DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
  5.Diabetes Center at Marienplatz, Munich, Germany
  6.Forschergruppe Diabetes e.V., Helmholtz Zentrum München, Neuherberg, Germany
  7.Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany
- Author bio：
  
  Vasilis Ntziachristos (bioimaging.translatum@tum.de)
- Funds：
- DOI：10.1038/s41377-023-01275-3
  中图分类号：
- 纸质出版日期：2023-11-30，
  
  网络出版日期：2023-09-18，
  
  收稿日期：2023-02-15，
  
  修回日期：2023-08-10，
  
  录用日期：2023-08-28
- Accepted：
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Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy[J]. LSA, 2023,12(11):2335-2349.

He, H. L. et al. Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy. Light: Science & Applications, 12, 2335-2349 (2023).
Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy[J]. LSA, 2023,12(11):2335-2349. DOI： 10.1038/s41377-023-01275-3.

He, H. L. et al. Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy. Light: Science & Applications, 12, 2335-2349 (2023). DOI： 10.1038/s41377-023-01275-3.

摘要

Abstract

Being the largest and most accessible organ of the human body

the skin could offer a window to diabetes-related complications on the microvasculature. However

skin microvasculature is typically assessed by histological analysis

which is not suited for applications to large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) for precise

non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy

resolved with unprecedented sensitivity and detail without the need for contrast agents. Providing unique imaging contrast

we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between different diabetes complications and microvascular features in vivo. We applied RSOM to scan the pretibial area of 95 participants with diabetes mellitus and 48 age-matched volunteers without diabetes

grouped according to disease complications

and extracted six label-free optoacoustic biomarkers of human skin

including dermal microvasculature density and epidermal parameters

based on a novel image-processing pipeline. We then correlated these biomarkers to disease severity and found statistically significant effects on microvasculature parameters as a function of diabetes complications. We discuss how label-free RSOM biomarkers can lead to a quantitative assessment of the systemic effects of diabetes and its complications

complementing the qualitative assessment allowed by current clinical metrics

possibly leading to a precise scoring system that captures the gradual evolution of the disease.

关键词

Keywords

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