A whispering-gallery scanning microprobe for Raman spectroscopy and imaging

Wenbo Mao; Yihang Li; Xuefeng Jiang; Zhiwen Liu; Lan Yang

doi:10.1038/s41377-023-01276-2

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A whispering-gallery scanning microprobe for Raman spectroscopy and imaging

Original Articles

- A whispering-gallery scanning microprobe for Raman spectroscopy and imaging
- A whispering-gallery scanning microprobe for Raman spectroscopy and imaging
- LSA 2023年12卷第11期页码：2402-2410
- Affiliations：
  
  1.Department of Electrical and Systems Engineering, Washington University, St Louis, MO 63130, USA
  2.Department of Electrical Engineering, Pennsylvania State University, University Park, PA 16802, USA
- Author bio：
  
  Lan Yang (yang@seas.wustl.edu)
- Funds：
- DOI：10.1038/s41377-023-01276-2
  中图分类号：
- 纸质出版日期：2023-11-30，
  
  网络出版日期：2023-10-05，
  
  收稿日期：2023-03-10，
  
  修回日期：2023-08-19，
  
  录用日期：2023-08-28
- Accepted：
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A whispering-gallery scanning microprobe for Raman spectroscopy and imaging[J]. LSA, 2023,12(11):2402-2410.

Mao, W. B. et al. A whispering-gallery scanning microprobe for Raman spectroscopy and imaging. Light: Science & Applications, 12, 2402-2410 (2023).
A whispering-gallery scanning microprobe for Raman spectroscopy and imaging[J]. LSA, 2023,12(11):2402-2410. DOI： 10.1038/s41377-023-01276-2.

Mao, W. B. et al. A whispering-gallery scanning microprobe for Raman spectroscopy and imaging. Light: Science & Applications, 12, 2402-2410 (2023). DOI： 10.1038/s41377-023-01276-2.

摘要

Abstract

Optical whispering-gallery-mode microsensors are a promising platform for many applications

such as biomedical monitoring

magnetic sensing

and vibration detection. However

like many other micro/nanosensors

they cannot simultaneously have two critical properties – ultrahigh sensitivity and large detection area

which are desired for most sensing applications. Here

we report a novel scanning whispering-gallery-mode microprobe optimized for both features and demonstrate enhanced Raman spectroscopy

providing high-specificity information on molecular fingerprints that are important for numerous sensing applications. Combining the superiorities of whispering-gallery modes and nanoplasmonics

the microprobe exhibits a two-orders-of-magnitude sensitivity improvement over traditional plasmonics-only enhancement; this leads to molecular detection demonstrated with stronger target signals but less optical power required than surface-enhanced-Raman-spectroscopy substrates. Furthermore

the scanning microprobe greatly expands the effective detection area and realizes two-dimensional micron-resolution Raman imaging of molecular distribution. The versatile and ultrasensitive scanning microprobe configuration will thus benefit material characterization

chemical imaging

and quantum-enhanced sensing.

关键词

Keywords

references

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