Submonolayer biolasers for ultrasensitive biomarker detection

Chaoyang Gong; Xi Yang; Shui-Jing Tang; Qian-Qian Zhang; Yanqiong Wang; Yi-Ling Liu; Yu-Cheng Chen; Gang-Ding Peng; Xudong Fan; Yun-Feng Xiao; Yun-Jiang Rao; Yuan Gong

doi:10.1038/s41377-023-01335-8

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Submonolayer biolasers for ultrasensitive biomarker detection

Original Articles

- Submonolayer biolasers for ultrasensitive biomarker detection
- Submonolayer biolasers for ultrasensitive biomarker detection
- LSA 2023年12卷第12期页码：2768-2777
- Affiliations：
  
  1.Key Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China
  2.Key Laboratory of Optoelectronic Technology and Systems (Ministry of Education of China), School of Optoelectronic Engineering, Chongqing University, Chongqing 400044, China
  3.State Key Laboratory for Mesoscopic Physics and Frontiers Science Centre for Nano-optoelectronics, School of Physics, Peking University, Beijing 100871, China
  4.School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore
  5.School of Electrical Engineering and Telecommunications, University of New South Wales, Sydney, NSW 2052, Australia
  6.Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
  7.Research Centre for Optical Fiber Sensing, Zhejiang Laboratory, Hangzhou, Zhejiang 310000, China
- Author bio：
  
  Yun-Feng Xiao (yfxiao@pku.edu.cn)
  Yun-Jiang Rao (yjrao@uestc.edu.cn)
  Yuan Gong (ygong@uestc.edu.cn)
- Funds：
- DOI：10.1038/s41377-023-01335-8
  中图分类号：
- 纸质出版日期：2023-12-31，
  
  网络出版日期：2023-12-06，
  
  收稿日期：2023-05-18，
  
  修回日期：2023-10-18，
  
  录用日期：2023-11-12
- Accepted：
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Submonolayer biolasers for ultrasensitive biomarker detection[J]. LSA, 2023,12(12):2768-2777.

Gong, C. Y. et al. Submonolayer biolasers for ultrasensitive biomarker detection. Light: Science & Applications, 12, 2768-2777 (2023).
Submonolayer biolasers for ultrasensitive biomarker detection[J]. LSA, 2023,12(12):2768-2777. DOI： 10.1038/s41377-023-01335-8.

Gong, C. Y. et al. Submonolayer biolasers for ultrasensitive biomarker detection. Light: Science & Applications, 12, 2768-2777 (2023). DOI： 10.1038/s41377-023-01335-8.

摘要

Abstract

Biomarker detection is key to identifying health risks. However

designing sensitive and single-use biosensors for early diagnosis remains a major challenge. Here

we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors. Telecom optical fibers serve as distributed optical microcavities with high Q-factor

great repeatability

and ultralow cost

which enables whispering-gallery laser emission to detect biomarkers. It is found that the sensing performance strongly depends on the number of gain molecules. The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection (LOD) when compared to saturated monolayer lasers. We further achieve an ultrasensitive immunoassay for a Parkinson's disease biomarker

alpha-synuclein (α-syn)

with a lower LOD of 0.32 pM in serum

which is three orders of magnitude lower than the α-syn concentration in the serum of Parkinson's disease patients. Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity.

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Keywords

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